细胞外细胞矩阵在再生医学中的支架:脱细胞化和临床应用的进展
Caijun Jin1,2, Xinrui Zhang1,2, Yongxun Jin1,2
1Department of Plastic and Reconstructive Surgery, College of Medicine, Seoul National University, Seoul 03080, Republic of Korea.
Journal of functional biomaterials
|October 28, 2025
概括
脱细胞化细胞外基质 (dECM) 支架为组织再生提供生物模拟模板. 标准化,免疫性和成本方面的挑战阻碍了临床转化,需要对患者特异性和生物制造疗法的进一步研究.
科学领域:
- 生物材料科学 生物材料科学
- 组织工程是组织工程.
- 再生医学是一种再生医学.
背景情况:
- 脱细胞化外细胞矩阵 (dECM) 支架保留了原生组织结构和生物化学信号.
- 这些支架作为仿生模板,促进细胞融合和组织重塑,同时最大限度地减少免疫反应.
研究的目的:
- 审查dECM研究的现状,包括脱细胞化技术,支架评估和应用.
- 分析商业dECM产品,临床试验和新兴技术,如3D生物打印和干细胞集成.
- 确定阻碍临床翻译的挑战,并提出未来的研究方向.
主要方法:
- 关于脱细胞化方法和支架质量评估试验的综合文献综述.
- 对特定组织的dECM应用 (皮肤,神经,心脏,肺,脂肪,胎盘) 的分析.
- 商业dECM产品的评估,临床试验,以及最近的技术进步.
主要成果:
- dECM支架在各种组织应用中显示出前景,目前正在进行临床试验和商用.
- 进步包括3D生物打印和将dECM与干细胞和生长因子结合起来.
- 主要挑战仍然存在:协议标准化,残留免疫性,机械性质以及监管/制造/成本障碍.
结论:
- 尽管取得了重大进展,但dECM疗法的临床转化仍受到几个因素的限制.
- 未来的方向强调患者特定的支架,可扩展的生物处理和综合生物制造.
- 开发安全有效的基于dECM的疗法需要解决这些多方面的挑战.
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