在真菌中 lncRNAs 的识别和功能
Javier Avalos1, Adrián Perera-Bonaño1, M Carmen Limón1
1Departamento de Genética, Facultad de Biología, Universidad de Sevilla, Av. de la Reina Mercedes, 6, 41012 Sevilla, Spain.
Non-coding RNA
|October 28, 2025
概括
长非编码RNA (lncRNAs) 越来越多地被认为具有跨物种的调节作用. 本综述强调了真菌lncRNAs,详细介绍了它们的识别和真菌转录组中的各种调节机制.
科学领域:
- 分子生物学分子生物学
- 菌类基因组学 菌类基因组学
- 在RNA生物学,RNA生物学.
背景情况:
- 长非编码RNAs (lncRNAs),转录≥200nt缺乏蛋白质编码潜力,最初被驳回,但现在已知具有调节功能.
- lncRNAs在多种类型中保存,真菌转录组显示出高于预期的丰度.
- 虽然酵母 lncRNAs 已被广泛研究,但其他真菌的详细研究正在迅速扩大.
研究的目的:
- 审查在真菌转录组中 lncRNA 存在的全球分析.
- 描述经过详细调查的特定的真菌 lncRNA.
- 突出菌 lncRNAs 的多样化的调节作用和机制.
主要方法:
- 对全球真菌转录组数据进行分析,以识别 lncRNAs.
- 进行比较基因组学以评估lncRNA的保存和分布.
- 关于特定真菌 lncRNAs 的详细案例研究的文献综述.
主要成果:
- lncRNAs在真菌中普遍存在,通常从基因间区域或重叠的蛋白质编码基因 (通常是反意义) 转录.
- 已识别的lncRNAs表现出多种不同的调节功能,在邻近的基因上或在遥远的目标上起作用.
- 关键机制包括转录干扰和在目标基因附近诱导表观遗传修饰.
结论:
- 菌 lncRNAs 代表了一类重要的非编码转录物.
- 它们的调节作用是多方面的,影响基因表达和表观遗传景观.
- 进一步的研究至关重要,以充分阐明真菌lncRNAs的功能表.
相关概念视频
lncRNA - Long Non-coding RNAs
9.8K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
9.8K
lncRNA - Long Non-coding RNAs
3.5K
3.5K
Types of RNA
72.5K
Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
72.5K
Types of RNA
9.0K
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
RNA Performs Diverse...
9.0K
Transcriptional Regulation: Riboswitches
559
Riboswitches are RNA elements that regulate gene expression by altering their secondary structures in response to specific effector molecules. These elements, located in the leader regions of certain mRNAs, act as transcriptional regulators by toggling between alternative conformations to control downstream gene expression. Riboswitch-mediated regulation is a precise mechanism for modulating biosynthetic pathways, as exemplified by the riboflavin biosynthesis pathway in Bacillus...
559
Yeast Signaling
17.1K
Yeasts are single-celled organisms, but unlike bacteria, they are eukaryotes (cells with a nucleus). Cell signaling in yeast is similar to signaling in other eukaryotic cells. A ligand, such as a protein or a small molecule released from a yeast cell, attaches to a receptor on the cell surface. The binding stimulates second-messenger kinases to activate or inactivate transcription factors that further regulate gene expression. Many of the yeast intracellular signaling cascades have similar...
17.1K


