肠-大脑轴和益生菌对阿尔茨海默病的影响
Raghad Tabaza1, Richard E Hartman1
1Department of Psychology, School of Behavioral Health, Loma Linda University, 11130 Anderson St., Loma Linda, CA 92354, USA.
Neurology international
|October 28, 2025
概括
益生菌可以通过影响肠-大脑轴,神经炎症和微生物平衡来缓解阿尔茨海默病 (AD) 的症状. 特定菌株对早期阿尔茨海默病和轻度认知障碍有希望.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 胃肠病学 胃肠病学
背景情况:
- 肠-大脑轴显著影响神经健康.
- 阿尔茨海默病 (AD) 涉及肠道微生物群和大脑之间的复杂相互作用.
- 新兴研究表明,益生菌在治疗AD中起着作用.
研究的目的:
- 审查关于肠-大脑轴,益生菌和阿尔茨海默病的当前文献.
- 确定益生菌可能影响AD的潜在机制.
- 讨论临床影响和未来的研究方向.
主要方法:
- 使用PRISMA指南进行系统的文献搜索.
- 搜索的数据库包括PubMed,临床试验.gov和谷歌学者.
- 分析研究的研究,研究治疗阿尔茨海默病和认知障碍的益生菌干预措施.
主要成果:
- 益生菌显示出通过调节神经炎症,肠道微生物组成和神经递质信号传递来减少AD症状的潜力.
- 像*Bifidobacterium breve*和*Lactobacillus plantarum*这样的特定菌株在早期阿尔茨海默病和轻度认知障碍方面表现出好处.
- 关键的机制包括影响免疫信号,神经递质合成 (GABA,血清素) 和减少系统性炎症.
结论:
- 益生菌代表了阿尔茨海默病的潜在治疗途径,特别是在早期阶段.
- 需要进一步研究更长的干预期和标准化益生菌菌株.
- 了解肠-大脑轴对于开发新的AD治疗方法至关重要.
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