使用WHONET和R:现实世界应用和R代码集成监测抗菌素耐药性趋势的六步协议
Fabio Ingravalle1, Antonio Vinci1, Marco Ciotti2
1Department of Biomedicine and Prevention, Tor Vergata University of Rome, 00133 Rome, Italy.
Methods and protocols
|October 28, 2025
概括
在全球范围内,对抗生素耐药性 (AMR) 的监测至关重要. 这项研究详细介绍了使用免费的WHOnet和R软件进行可复制的AMR趋势分析,以帮助公共卫生决策.
科学领域:
- 微生物学 微生物学
- 公共卫生 公共卫生
- 生物信息学是一种生物信息学.
背景情况:
- 抗菌素耐药性 (AMR) 是一个重大的全球健康威胁.
- 由于资源和知识的局限性,现有的抗药性耐药性监测工具未得到充分利用.
- 世卫组织为AMR监测开发了免费软件WHOnet和R.
研究的目的:
- 使用WHOnet和R.提供标准化,可重复的工作流程,用于回顾性AMR趋势分析.
- 为实施AMR监测提供实用,逐步的说明和R代码.
- 用意大利一家医院的现实数据来证明这些工具的实用性.
主要方法:
- 利用WHOnet进行实验室数据和抗菌素敏感性测试 (AST) 结果管理.
- 使用R,一个统计编程语言,用于数据分析和可视化.
- 将WHOnet和R结合起来,建立一个可重复的AMR趋势分析工作流程.
主要成果:
- 通过使用真实世界的数据,展示了可复制的工作流程,用于回顾性AMR趋势分析.
- 提供了用于标准化AMR数据分析的功能R代码.
- 用意大利医院环境中的数据说明了工作流程的应用.
结论:
- 使用WHOnet和R的标准化AMR分析提高了临床医生和公共卫生专业人员的数据可用性.
- 快速获取抗菌耐药性数据支持基于证据的实证抗菌治疗决策.
- 描述的方法方便在不同的医疗保健环境中有效监测和管理AMR.
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