相关实验视频

Updated: Jan 13, 2026

Modeling and Simulations of Olfactory Drug Delivery with Passive and Active Controls of Nasally Inhaled Pharmaceutical Aerosols

Modeling and Simulations of Olfactory Drug Delivery with Passive and Active Controls of Nasally Inhaled Pharmaceutical Aerosols

Published on: May 20, 2016

一种几何形态测量方法来预测嗅觉区域的可访问性:朝着个性化鼻至大脑药物输送

Priya Vishnumurthy^1,2, Thomas Radulesco³, Gilles Bouchet²

¹Nemera La Verpillière, 69007 Lyon, France.

Journal of personalized medicine

|October 28, 2025

概括

鉴定出了三个不同的鼻腔形状,影响药物输送到大脑. 这些形态型通过了解感兴趣区域的解剖学变异,为个性化鼻至脑治疗提供了洞察力.

科学领域:

解剖学和生理学的解剖学和生理学
药理学药理学是指药理学的学科.
医疗成像医学成像

背景情况:

鼻腔解剖学显著影响鼻内药物递送的疗效,特别是针对嗅觉区域的鼻至脑治疗.
以前的研究依赖于平均模型或2D测量,忽视了感兴趣的嗅觉区域 (ROI) 中的3D形状变化.
对于嗅觉药物向至关重要的ROI的3D形态变异性以前没有被探索过.

研究的目的:

用几何形态测量来研究鼻腔感兴趣区域 (ROI) 的3D解剖变异性.
在ROI中识别不同的形态集群,可能会影响鼻内药物可访问性.
为个性化鼻至脑药物输送策略提供基础.

主要方法:

从78名患者的CT扫描中对151个单侧鼻腔进行几何形态分析.
在ROI中对地标和半地标进行数字化,然后进行通用Procrustes分析以实现标准化.
主要组件分析 (PCA) 和主体组件层次聚类 (HCPC) 以识别和描述形态集群.

主要成果:

确定了三种不同的ROI形态集群,沿X和Y轴有显著的形状变化.
集群1呈现出更宽的前腔和更浅的轮机,可能提高嗅觉可访问性.
集群3呈现较窄的腔与更深的轮机,可能限制嗅觉可访问性;集群2是中间的.

结论:

该研究确定了三个不同的鼻腔形态型,影响药物颗粒进入嗅觉区域.
这些发现对于计算流体动力学研究至关重要,旨在优化鼻腔药物向.
鉴定到的形态型代表了个性化医学的一步,用于鼻至大脑药物输送.

关键词:

解剖学集群的解剖学集群几何形态形态测量是几何形态的.鼻腔的可变性鼻腔的可变性鼻子到大脑的连接.嗅觉区域的可访问性嗅觉区域的可访问性个性化医疗是个性化的医疗.半标志性的地标.

更多相关视频

Novel Methods for Intranasal Administration Under Inhalation Anesthesia to Evaluate Nose-to-Brain Drug Delivery

Novel Methods for Intranasal Administration Under Inhalation Anesthesia to Evaluate Nose-to-Brain Drug Delivery

Published on: November 14, 2018

Author Spotlight: Exploring Olfactory Influences on Corticospinal Excitability - Insights and Innovations in Neurological Research

Author Spotlight: Exploring Olfactory Influences on Corticospinal Excitability - Insights and Innovations in Neurological Research

Published on: January 19, 2024

相关概念视频

Olfaction

Olfaction

The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...

Physiology of Smell and Olfactory Pathway

Physiology of Smell and Olfactory Pathway

Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
The olfactory...

Olfactory Receptors: Location and Structure

Olfactory Receptors: Location and Structure

The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...