乳头甲状腺癌中的后宫淋巴结转移:复发和瘤结果的预测因素
Andrea Migliorelli1, Marianna Manuelli1, Agnese Maria Tringali1
1ENT & Audiology Unit, Department of Neurosciences, University Hospital of Ferrara, 44100 Ferrara, Italy.
Journal of personalized medicine
|October 28, 2025
概括
乳头甲状腺癌的复发与甲状腺外延伸,瘤大小和淋巴结比率 (LNR) 有关. 超过0.205的LNR有效预测复发,帮助量身定制的患者治疗策略.
科学领域:
- 在瘤学瘤学.
- 内分泌学 在内分泌学.
- 手术病理学手术病理学
背景情况:
- 乳头甲状腺癌 (PTC) 是最常见的甲状腺恶性瘤.
- 侧侧宫淋巴结转移 (I-V级) 显著影响复发率.
- 预测复发对于优化患者管理策略至关重要.
研究的目的:
- 在PTC中确定横向宫淋巴结转移的预测因素.
- 为了确定PTC患者疾病复发的预测因素.
- 用接收器操作特征 (ROC) 曲线分析来确定淋巴结比率 (LNR) 的切断值,作为瘤复发的指标.
主要方法:
- 追溯观察性研究分析了43名PTC患者的临床病历.
- 患者接受了甲状腺切除术,并进行侧部和中部部解剖.
- 与单独接受全甲状腺切除术的对照组进行比较.
主要成果:
- 甲状腺外延伸,瘤大小,淋巴结参与和LNR是PTC复发的显著预测因素 (p <0.001到0.022).
- ROC分析发现LNR>0.205作为复发的预测因素 (AUC0.818,灵敏度82%,特异性81%).
- fT4水平,瘤大小和酒精消费预测了淋巴结转移 (p < 0.001 到 0.019).
结论:
- 甲状腺外延伸,瘤大小,淋巴结状况和LNR与PTC复发有关.
- 对于评估PTC复发风险,LNR是一个可靠的指标.
- 预测因素可以帮助为PTC患者量身定制临床方法.
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