Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

4.2K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
4.2K
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

4.1K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
4.1K
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

1.2K
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
1.2K
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

703
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
703
COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

1.7K
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
1.7K
The Bronchial Tree01:23

The Bronchial Tree

6.1K
The human bronchi and bronchial tree play a crucial role in the respiratory system, facilitating the exchange of oxygen and carbon dioxide. Let's delve into the intricate structure and functions of these respiratory components.
The trachea, commonly known as the windpipe, is a tube that connects the larynx (voice box) to the bronchi. At a point called the carina, it bifurcates into two primary bronchi. The right primary bronchus is wider, shorter, and more vertical than the left primary...
6.1K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Real-World Effectiveness and Safety of Extrafine Triple Therapy in COPD Patients with Comorbid and Cardiovascular Conditions.

International journal of chronic obstructive pulmonary disease·2026
Same author

Is Mediterranean diet associated with severe asthma control? A multi-center cross-sectional study in Greece.

The Journal of asthma : official journal of the Association for the Care of Asthma·2026
Same author

Decoding sarcoidosis chronicity through phenotypic profiling.

Therapeutic advances in respiratory disease·2026
Same author

The role of artificial intelligence in predicting COPD exacerbations using multimodal data: a systematic review.

ERJ open research·2026
Same author

Application of the Idiopathic Pulmonary Fibrosis Patient-Reported Outcome Measure (IPF-PROM) scale to a Greek IPF patient population and its interrelation with depressive symptoms and health-related quality of life.

BMJ open respiratory research·2026
Same author

Polyunsaturated fatty acid-derived lipid mediator patterns determine viral pneumonia severity and risk for critical COVID-19.

Proceedings of the National Academy of Sciences of the United States of America·2026

相关实验视频

Updated: Jan 13, 2026

Long Term Chronic Pseudomonas aeruginosa Airway Infection in Mice
15:43

Long Term Chronic Pseudomonas aeruginosa Airway Infection in Mice

Published on: March 17, 2014

23.7K

支气管切除症的炎症表型

Evangelia Koukaki1, Georgia Papaiakovou1, Argyri Klironomou1

  • 11st Respiratory Medicine Department of National and Kapodistrian University of Athens, Sotiria Chest Diseases Hospital, 11527 Athens, Greece.

Journal of personalized medicine
|October 28, 2025
PubMed
概括

支气管切除症表现出多种不同的炎症特征,而不仅仅是中性粒细胞驱动的. 识别这些表型,如中性友好或异友好,指导个性化治疗,以获得更好的患者结果.

关键词:
生物标志物 生物标志物支气管切除症是一种支气管切除.中性恋性炎症是一种中性恋炎症.现象类型 现象类型精准医学是一门精准医学.

更多相关视频

Identification and Characterization of Immunogenic RNA Species in HDM Allergens that Modulate Eosinophilic Lung Inflammation
08:44

Identification and Characterization of Immunogenic RNA Species in HDM Allergens that Modulate Eosinophilic Lung Inflammation

Published on: May 30, 2020

6.5K
Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy
10:39

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy

Published on: April 16, 2019

8.1K

相关实验视频

Last Updated: Jan 13, 2026

Long Term Chronic Pseudomonas aeruginosa Airway Infection in Mice
15:43

Long Term Chronic Pseudomonas aeruginosa Airway Infection in Mice

Published on: March 17, 2014

23.7K
Identification and Characterization of Immunogenic RNA Species in HDM Allergens that Modulate Eosinophilic Lung Inflammation
08:44

Identification and Characterization of Immunogenic RNA Species in HDM Allergens that Modulate Eosinophilic Lung Inflammation

Published on: May 30, 2020

6.5K
Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy
10:39

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy

Published on: April 16, 2019

8.1K

科学领域:

  • 肺部医学 肺部医学
  • 免疫学 免疫学 免疫学
  • 呼吸系统疾病研究 呼吸系统疾病研究

背景情况:

  • 支气管切除症是一种复杂的慢性呼吸道疾病.
  • 传统上被认为是中性粒细胞驱动的,但最近的证据突出显示了多种不同的炎症表型.
  • 这些表型会影响临床结果,预后和治疗策略.

研究的目的:

  • 审查和描述支气管炎症中独特的炎症表型.
  • 探索每个表型的临床影响和潜在的治疗点.
  • 强调在支气管切除症管理中转向个性化,生物标志物引导的护理.

主要方法:

  • 科学文献的叙事评论. 科学文献的叙事评论.
  • 在PubMed和Google Scholar上进行结构化的文献搜索.
  • 专注于基于细胞群的炎症表型的识别和表征.

主要成果:

  • 确定了四种不同的表型:中性友好型,乙性友好型,混合型和 paucigranulocytic.
  • 与 Pseudomonas 感染,严重疾病和不良预后相关的中性性表型.
  • 乙酸性表型与乙酸细胞,FeNO的升高相关,以及对皮质类固醇/生物制剂的潜在反应.
  • 混合型和小粒细胞型表型具有独特的特征,需要进一步研究.
  • 新兴的向疗法包括中性粒细胞蛋白酶抑制剂 (例如,brensocatib).

结论:

  • 支气管切除症呈现了一系列具有显著生物和临床差异的炎症表型.
  • 了解这些表型对于开发个性化治疗策略至关重要.
  • 过渡到生物标志物指导护理为支气管切除症的精准医学提供了机会.