相关实验视频

Updated: Jan 13, 2026

Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids

Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids

Published on: April 25, 2016

普雷尼索隆治疗对猫的血清胆酸度的影响

Militsa Pacheva¹, Daniel Brugger², Barbara Riond³

¹Clinic for Small Animal Internal Medicine, Vetsuisse Faculty, University of Zurich, 8057 Zurich, Switzerland.

Veterinary sciences

|October 28, 2025

概括

猫的口服普雷迪尼索隆显著增加了血清胆酸,但降低了ALT和AST等肝酶. 这些变化是微小的,可能对猫的健康没有临床意义.

科学领域:

兽医医学兽医医学兽医医学
药理学药理学是指药理学的学科.
生物化学生物化学

背景情况:

已知皮质类固醇会影响人类和狗的胆酸代谢.
皮质类固醇对猫胆酸代谢和早期肝酶活性的特定影响仍然在很大程度上未被描述.

研究的目的:

为了研究口服普雷迪尼索隆对血清胆汁酸和肝酶活动 (ALT,AST,ALP,GT) 的影响,在健康的猫身上.
为了确定任何观察到的变化的临床相关性.

主要方法:

这是一项前性研究,涉及七只健康的猫,每天接受口服普雷迪尼索隆 (1.1-1.5毫克/公斤) 治疗七天.
血清胆汁酸和肝酶在治疗前,治疗期间和治疗后的多个时间点进行测量.
统计分析包括弗里德曼测试和后期比较.

主要成果:

血清胆汁酸在普得尼索隆治疗期间显著增加,达到5.3μmol/L的中位数,但仍低于临床异常水平.
阿斯巴酸氨基转移酶 (AST),氨基转移酶 (ALT) 和性酸酶 (ALP) 的活性在普雷迪尼索隆的使用过程中显著下降.
在整个研究期间,GGT活动无法检测到.

结论:

普雷迪尼索隆在猫的使用导致血清胆汁酸的统计学上显著但临床上最小的增加.
意想不到的是,在前尼索隆治疗的初始阶段,肝酶活性 (AST,ALT,ALP) 降低,潜在的原因需要进一步调查.

关键词:

胆汁酸胆汁酸胆汁酸猫和猫咪,它们都是猫咪.皮质类固醇是什么肝脏酶肝脏酶肝脏酶

更多相关视频

Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport

Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport

Published on: November 27, 2016

Isolation and 3D Collagen Sandwich Culture of Primary Mouse Hepatocytes to Study the Role of Cytoskeleton in Bile Canalicular Formation In Vitro

Isolation and 3D Collagen Sandwich Culture of Primary Mouse Hepatocytes to Study the Role of Cytoskeleton in Bile Canalicular Formation In Vitro

Published on: December 20, 2019

相关概念视频

Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids

Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids

Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...