饮食益生菌在减少阿弗拉托克辛B毒性的全面审查1毒性
Dasol Choi1, Xingrui Fan2,3, Jae-Hyuk Yu3,4
1Department of Materials Science & Engineering, University of California, Los Angeles, CA 90095, USA.
Toxins
|October 28, 2025
概括
益生菌乳酸细菌在减少阿弗拉托辛B1 (AFB1) 吸收和毒性方面表现有前途. 这些有益的细菌可能提供一种生物策略来对抗AFB1诱导的肝癌.
科学领域:
- 微生物学 微生物学
- 毒理学 毒理学 毒理学
- 胃肠病学 胃肠病学
背景情况:
- 甲毒素B1 (AFB1) 是一种与肝癌相关的强有力的真菌毒素.
- 现有的排毒方法有局限性,这引发了对生物解决方案的兴趣.
- 益生菌干预正在被探索作为一种新的策略来对抗AFB1毒性.
研究的目的:
- 审查益生菌乳酸细菌对AFB1.1的疗效的体内和临床证据.
- 概括益生菌减轻AFB1吸收和毒性的机制.
- 评估益生菌作为AFB1诱导肝细胞癌 (HCC) 的对策的潜力.
主要方法:
- 临床前 (体内) 和临床研究的系统综述.
- 分析机理性见解,包括细胞壁吸附,肠道微生物群调节和屏障保护.
- 对AFB1生物标志物和益生菌补充剂的临床试验数据的评估.
主要成果:
- 益生菌乳酸细菌在临床前模型中显示出降低AFB1吸收和毒性的潜力.
- 机制包括AFB1的物理结合,肠道微生物群的调节,增强肠道屏障功能和抗氧化作用.
- 临床试验表明,使用益生菌可以减少AFB1生物标志物,尽管证据有限.
结论:
- 益生菌乳酸细菌代表了一种有前途的生物方法来缓解AFB1毒性.
- 需要进一步的精心设计的临床试验来确认疗效并建立最佳的方案.
- 益生菌可以在预防AFB1诱导的肝细胞癌方面发挥作用.
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