一个基于Verilog-A的氧-信号传导模型,用于共模拟表面电化学生物传感器和电路
IEEE transactions on biomedical circuits and systems
|October 28, 2025
概括
一个新的紧型电化学电池模型准确地模拟了表面绑定的基于电化学吸收器 (E-AB) 的电化学传感器及其读出电路. 这种物理接地模型可以提高生物传感器开发和持续监控应用的模拟精度.
科学领域:
- * 电化学生物传感器建模
- *用于生物传感应用的电路模拟.
背景情况:
- * 表面结合的基于电化学吸收体 (E-AB) 的传感器为持续的生物分子监测提供了高选择性和灵敏度.
- *由于复杂的电极-电解质接口行为和电子转移动力学,对E-AB传感器与读出电路的准确共模拟具有挑战性.
研究的目的:
- * 开发一个紧的,与SPICE兼容的电化学电池模型,用于表面绑定的E-AB传感器.
- * 提高生物传感器电路模拟的物理解释性和数值稳定性.
主要方法:
- * 实现了一个Verilog-A模型,将马库斯-赫什电子转移动力学与电双层 (EDL) 的分数顺序RC梯次表示相结合.
- * 在两个E-AB传感器上使用方波电压测量 (SWV) 在各种频率和度上验证了模型.
- * 同时模拟模型与传 impedance 放大器,以与实验数据比较电子噪声光谱.
主要成果:
- * 该模型准确地捕获了电子转移动力学,热力学和度响应 (Langmuir等热量).
- * 模拟过渡电流与实验数据保持一致.
- *与传 impedance 放大器共同模拟产生了与实验结果密切匹配的电子噪声光谱,其性能优于简化的 Randles 电路模型.
结论:
- * 拟议的模型提供了一个物理接地框架,用于模拟表面结合的基于氧化还原的电化学生物传感器.
- * 可实现E-AB传感器与读出电路的准确共模拟,促进生物传感器的设计和开发.
- * 推进了持续的in-vivo和in-vitro生物分子监测能力.
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