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在健康个体中,nocebo效应比安慰剂效应更强大,更持久

Angelika Kunkel¹, Katharina Schmidt¹, Helena Hartmann¹

¹Department of Neurology, Center for Translational Neuro- and Behavioral Sciences (C-TNBS), University Medicine Essen, University Duisburg-Essen, Essen, Germany.

|October 28, 2025

概括

对疼痛的nocebo效应比安慰剂效应更强大,更持久. 了解这些差异对于管理患者的期望和改善疼痛管理的临床结果至关重要.

科学领域:

心理学心理学心理学
神经科学是一个神经科学.
疼痛管理疼痛管理

背景情况:

安慰剂和安慰剂效应显著影响症状感知和治疗结果.
假药与nocebo效应的比较强度和持续时间仍未得到充分研究.
认知情感过程对医疗干预的反应产生了深刻的影响.

研究的目的:

直接比较安慰剂和nocebo效应对实验性疼痛的影响的大小和持久性.
为了研究这些影响在1周的时间内持久的性质.
为了确定持续的安慰剂和安慰剂反应的预测因素.

主要方法:

在104名健康个体中采用了主体内设计.
使用口头指令和调节诱导了安慰剂和无效果.
疼痛感知在诱导后立即评估,并在1周的随访后进行评估.

主要成果:

在第1天和第8天,观察到显著的安慰剂和无效果对疼痛的影响.
与安慰剂效应相比,nocebo效应始终表现出更大的强度.
一周后持续的效果是由第1天经历的效应的大小预测的.

结论:

对疼痛的安慰剂和安慰剂效应是持久的现象.
诺塞博反应通常比安慰剂反应强,可能反映了一个进化"比抱歉更安全"机制.
缓解nocebo效应的影响应该是临床实践中的优先事项,以提高患者的护理.

关键词:

调节条件的调节条件人类人类人类人类人类人类人类神经科学神经科学没有nocebo的过敏症.疼痛调节和疼痛调节的方法避孕药催眠效应催眠效应治疗期望治疗期望

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