在PAH诱导的儿童喘表观遗传变化:使用硫黄的干预
Xinyao Jiang1,2, Xinfeng Xu1,2, Jinyan Hui1,2
1China International Cooperation Center (CCC) for Environment and Human Health, School of Public Health, Nanjing Medical University, Nanjing 211166, China.
Toxics
|October 28, 2025
概括
多环芳 (PAHs) 与儿童喘有关,DNA甲基化作为关键调解剂. 硫法 (SFN) 可以逆转这些有害的表观遗传变化,提供潜在的预防策略.
科学领域:
- 环境表观遗传学环境表观遗传学
- 儿科肺病学 儿科肺病学
- 毒理学 毒理学 毒理学
背景情况:
- DNA甲基化对于检测组织损伤和识别多环芳 (PAH) 相关儿童喘的生物标志物至关重要.
- 硫氨酸 (SFN) 显示出作为一种表观遗传调节剂的潜力,可以减轻环境污染物的影响.
研究的目的:
- 调查DNA甲基化在PAH和儿童喘之间的关联中的调解作用.
- 探索甲 (BaP) 和SFN对肺细胞和小鼠模型中的表观遗传修饰和基因表达的影响.
主要方法:
- 在370名儿童的血清中量化PAH,使用气色谱-质谱.
- 通过二硫酸盐测序PCR (BSP) 评估基因甲基化,并进行中介分析.
- 使用的小鼠模型和体外细胞培养 (HBE,HBSMCs) 暴露于BaP和/或SFN.
主要成果:
- 与儿童喘相关的PAH总量,通过长间隔的核元素-1 (LINE-1) 甲基化介导.
- 暴露于PAH改变了DNA甲基化模式,特别是ECM受体相互作用和 purin代谢途径.
- BaP通过低甲基化对炎症性细胞因子和矩阵金属化酶9 (MMP9) 进行上调;SFN逆转了这些效应.
结论:
- 基因甲基化显著调解PAH暴露和儿童喘之间的联系,根据暴露时间有不同的模式.
- 在PAH引起的肺炎中,MMP9是表观遗传干预的关键标.
- SFN在逆转PAH诱导的表观遗传改变方面表现出有效性,支持其在预防策略中的作用.
更多相关视频
相关概念视频
Asthma: Pathogenesis and Management
1.2K
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
1.2K
Antiasthma Drugs: Leukotriene Modifiers
1.7K
Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
Leukotriene modifiers work through two distinct mechanisms:
1.7K
Asthma-II: Pathophysiology and Classification
4.1K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
4.1K
Asthma-I: Introduction
3.4K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
3.4K
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
1.7K
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
1.7K


