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6PPD和6PPDQ的环境和人类健康风险:评估和影响

Sainan Zhang¹, Jiayue Tang¹, Zhiying Qiu¹

¹School of Public Health, Zhejiang Chinese Medical University, 548 Binwen Road, Hangzhou 310053, China.

|October 28, 2025

概括

轮胎磨损颗粒会释放N-(1,3-二甲基) -N'--p-phenylenediamine (6PPD) 和6PPD- (6PPDQ),造成生态风险. 人类暴露得到证实,但对健康的影响需要进一步研究.

科学领域:

环境科学环境科学
毒理学毒理学毒理学
生态毒理学生态毒理学

背景情况:

轮胎磨损颗粒 (TWPs) 是环境污染物的重要来源.
N-(1,3-二甲基) -N"--p-phenylenediamine (6PPD) 和其转化产品6PPD- (6PPDQ) 是TWP衍生的关键污染物.

研究的目的:

综合有关6PPD和6PPDQ在环境中的分布,转化,暴露和毒理学影响的当前知识.
评估与这些轮胎磨损污染物相关的生态和人类健康风险.

主要方法:

环境监测,毒理学研究 (水生和哺乳动物模型) 和人类生物监测研究的综合文献综述.
对污染物度,毒理终点 (例如LC50,氧化应激,基因毒性) 和暴露途径的数据分析.

主要成果:

6PPD和6PPDQ在空气,水,土壤,沉积物和尘埃中无处不在.
6PPDQ具有很高的水生毒性 (例如,科霍鱼LC50=790 ng/L).
通过吸入,摄入和皮肤接触的人类暴露得到证实;在血液,尿液和脑脊液中检测到化合物.
毒理学研究表明有氧化应激,DNA损伤,代谢和神经干扰,肠道毒性,生殖功能障碍和神经行为变化的潜力.
发现了显著的生态风险,特别是来自6PPDQ;对人类健康的影响尚未完全理解.

结论:

6PPD和6PPDQ是普遍存在的环境污染物,具有相当大的生态风险,特别是对水生生物的风险.
确定的人类暴露需要进一步研究长期健康影响.
迫切需要纵向环境跟踪,机制研究和精细的暴露模型,以告知风险减轻和监管行动.

关键词:

电子垃圾是一种电子垃圾.新出现的污染物新出现的污染物环境持久性环境持久性微塑料微塑料的使用的添加剂的添加剂轮胎磨损颗粒 (TWPs) 是指轮胎的磨损颗粒.

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