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在NICU中产前新生儿对重金属和微量元素的周产期暴露:使用多个生物基质的毒理学研究
Melda Celik1, Irem Iyigun2, Siddika Songül Yalcin1
1Division of Social Pediatrics, Department of Pediatrics, Sıhhiye, 06100 Ankara, Türkiye.
Toxics
|October 28, 2025
概括
过早出生的婴儿持续暴露于重金属和微量元素,其水平在母体和新生儿样本之间有所不同. 对于照顾这些脆弱新生儿的医疗保健提供者来说,产前环境暴露意识至关重要.
科学领域:
- 环境健康 环境健康
- 新生儿毒理学 新生儿毒理学
- 围产儿医学 围产儿医学
背景情况:
- 过早出生的婴儿面临着独特的健康挑战,包括可能接触到环境污染物.
- 了解这种人群中的重金属和微量元素的转移和积累对于评估健康风险至关重要.
研究的目的:
- 调查早产婴儿 (<35周妊娠期) 的母亲尿液,新生儿尿液和带血中的重金属和微量元素水平 (Hg,Pb,Cd,As,Mn,Se,Cu).
- 探索这些元素水平与母亲/新生儿特征之间的关系.
- 评估过胎儿和持续暴露路径在早产新生儿.
主要方法:
- 分析母亲尿液,新生儿尿液和带血样本中的重金属和微量元素.
- 在不同的生物矩阵中比较元素含量.
- 元素含量与孕产妇/新生儿参数之间的相关性分析 (例如,孕产妇年龄,阴茎长度,阴道距离,出生体重百分比).
主要成果:
- 带血中Pb,As和Hg的含量低于母亲的尿液,而Se和Cu的含量更高.
- 与新生儿尿液相比,母亲的尿液显示出所有元素的分泌量更高.
- 新生儿尿液中Cd,Mn,Se和Cu的含量低于带血,而As和Hg的含量更高.
- 在孕产妇和新生儿的铜,孕产妇的和孕产妇的年龄之间观察到显著的正相关性.
- 在某些元素 (NuHg,MuMn,带Mn) 和阴茎长度/生殖器距离之间发现了负相关性;新生儿Pb与出生体重百分位数正相关.
- 新生儿尿液中的金属分泌量随着时间的推移显著增加.
结论:
- 研究结果表明,胎盘传播和持续暴露于重金属和微量元素在早产婴儿.
- 该研究强调了在照顾早产新生儿时考虑产前环境暴露的重要性.
- 建议医疗保健提供者提高对影响早产婴儿健康的环境因素的认识.
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