冠状动脉疾病的多基因风险评分在动脉样硬化疾病的谱中
Andre Zimerman1,2, Frederick K Kamanu3, Giorgio E M Melloni3
1Academic Research Organization, Hospital Moinhos de Vento, Moinhos de Vento College of Health Sciences, Porto Alegre, Brazil.
European journal of preventive cardiology
|October 28, 2025
概括
冠状动脉疾病 (CAD) 的多基因风险评分有助于预测动脉样硬化心血管疾病 (ASCVD) 所有阶段的心脏事件. 虽然基因在没有ASCVD患者中显示出更强的相对影响,但所有患者的绝对风险增加是相似的.
科学领域:
- 心血管医学 心血管医学
- 遗传学 遗传学 是一个
- 流行病学 流行病学
背景情况:
- 冠状动脉疾病 (CAD) 的多基因风险评分 (PRS) 对风险分层有价值.
- 在动脉样硬化心血管疾病 (ASCVD) 范围内的CAD PRS的差异效用仍然不清楚.
研究的目的:
- 为了比较CAD PRS与已确定的ASCVD患者,没有先前事件的ASCVD患者和没有明显的ASCVD患者的冠状动脉事件的关联.
主要方法:
- 一个全基因组的CAD PRS被用来将来自6个跨国心血管试验的59,905名参与者分为低,中,高遗传风险组.
- 参与者按ASCVD状态分组:具有先前的缺血事件,没有事件的ASCVD和没有明显的ASCVD.
- 主要终点是主要冠状动脉事件的组合,包括冠状动脉疾病导致的死亡,心肌梗塞或冠状动脉再血管化.
主要成果:
- 与低遗传风险组相比,高和中等遗传风险组的重大冠状动脉事件更频繁 (HRs分别为2.06和1.57).
- 遗传风险和主要冠状动脉事件之间的关联在没有明显ASCVD的患者中最强 (HR 4.63对于高风险和低风险).
- 在所有ASCVD类别中,高和低遗传风险之间的重大冠状动脉事件的绝对风险差异是可比的,在3年内从5.0%到7.0%不等.
结论:
- 在所有类别的ASCVD中,CAD PRS与突发性主要冠状动脉事件有关.
- 虽然PRS在没有确定的ASCVD的个体中显示出更强的相对风险关联,但无论ASCVD状态如何,绝对风险增加是相似的.
更多相关视频
06:57Author Spotlight: Advancing Cardiovascular Imaging - Introducing the Spatially Weighted Calcium Score for Early Disease Detection
Published on: September 22, 2023
1.4K
08:51Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts
Published on: September 20, 2024
2.0K
相关概念视频
01:25Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT
381
Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
381
01:30Coronary Artery Disease I: Introduction
869
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
869
01:18Polygenic Traits
68.8K
When more than one gene is responsible for a given phenotype, the trait is considered polygenic. Human height is a polygenic trait. Studies have uncovered hundreds of loci that influence height, and there are believed to be many more. Due to the high number of genes involved, as well as environmental and nutritional factors, height varies significantly within a given population. The distribution of height forms a bell-shaped curve, with relatively few individuals in the population at the...
68.8K
01:11Genome-wide Association Studies-GWAS
15.3K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
15.3K
01:26Coronary Artery Disease II: Pathophysiology
360
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
360
01:26Coronary Artery Disease IV: Preventive Measures
580
Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
580