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在菲律宾农村地区对新型肺结核快速诊断试验的早期成本效益分析

Aren Sargood¹, Abigail Ortal-Cruz², Rusheng Chew^3,4

¹Oriel College, University of Oxford, Oxford, United Kingdom.

PLOS global public health

|October 28, 2025

概括

一种新的快速分子诊断测试 (nLRDT) 具有成本效益,用于在菲律宾农村地区诊断结核病. 这种新的测试,使用舌头拭子,在低资源环境中提供了Xpert MTB/RIF的可行替代方案.

科学领域:

全球健康全球健康
诊断技术诊断技术诊断技术
卫生经济学卫生经济学

背景情况:

结核病 (TB) 不成比例地影响低收入和中等收入国家 (LMICs).
在分散的初级医疗保健机构中,访问像Xpert MTB/RIF这样的金标准分子诊断分析通常是有限的.
一种使用舌头拭片的新型快速分子诊断测试 (nLRDT) 已开发,以提高可访问性.

研究的目的:

评估nLRDT的早期成本效益与Xpert MTB/RIF相比,用于肺结核诊断.
评估菲律宾农村初级医疗保健机构的医疗保健提供者和社会观点的成本效益.

主要方法:

采用混合决策树和基于马尔科夫模型的成本效益分析.
参数来源于文献,国家数据和专家意见.
分析成本为2024美元,用于评估的支付意愿 (WTP) 门.

主要成果:

从提供者和社会角度来看,nLRDT使用唾液和舌头片样本证明了成本效益.
净货币收益 (NMB) 在样本类型和视角上对nLRDT是积极的.
确定了nLRDT的特异性是影响其成本效益的关键因素.

结论:

在菲律宾农村,nLRDT为肺结核提供了一种具有成本效益的诊断解决方案.
研究结果表明,在全球类似的低资源环境中,它可能适用.
该研究强调了诊断可访问性对研究,工业和卫生政策制定的积极影响.

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