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高葡萄糖度对PC12细胞的影响:可能对神经退行产生影响

Claudia Cannas1, Grazia Galleri2, Laura Doro1

  • 1Department of Medicine, Surgery and Pharmacy, University of Sassari, Viale San Pietro 43/b, 07100 Sassari, Italy.

Current issues in molecular biology
|October 28, 2025
PubMed
概括

高度的葡萄糖诱导神经元细胞损伤,增加氧化应激和亡,并减少细胞迁移. 这些发现表明高血糖和神经退行性疾病之间存在联系.

关键词:
在PC12细胞中,PC12细胞灭症 (apoptosis) 是一种死亡的过程.葡萄糖 葡萄糖 葡萄糖 是 一种神经退行症的神经退行症氧化应激是一种氧化应激.

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Diabetic Neuropathy01:22

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DefinitionDiabetic neuropathy is nerve damage caused by long-standing diabetes mellitus. It results directly from prolonged high blood sugar levels.PathophysiologyThe pathophysiology of diabetic neuropathy involves both metabolic and vascular disturbances triggered by chronic hyperglycemia.Metabolic injury: Elevated glucose levels activate the polyol pathway within nerve cells, leading to the accumulation of sorbitol and fructose. This increases oxidative stress, disrupts normal nerve...
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