脑卒中和糖尿病前期之间的病理生理学联系:系统性审查
Yerushka Naicker1, Andile Khathi1
1Department of Human Physiology, School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban 3629, South Africa.
Current issues in molecular biology
|October 28, 2025
概括
糖尿病前期可能会改变中风生物标志物如NSE,IL-6,D-二次体,GFAP和S100B,这表明早期的病理生理变化会增加中风风险. 需要进一步的研究来证实这些联系的早期检测.
科学领域:
- 内分泌学和神经病学 在内分泌学和神经病学.
- 生物标志物研究 生物标志物研究
- 心血管健康 心血管健康
背景情况:
- 糖尿病前期代表了2型糖尿病 (T2DM) 之前的关键阶段,影响全球超过4.25亿人.
- 这一阶段与血管损伤和中风风险增加有关,但这种联系仍未得到充分研究.
- 了解糖尿病前期中风生物标志物对于早期干预至关重要.
研究的目的:
- 系统地审查和综合有关正常血糖,糖尿病前期和T2DM中风相关生物标志物的现有文献.
- 通过生物标志物分析,识别糖尿病前期和中风之间的潜在关联.
- 探索早期的病理生理变化,表明糖尿病前期患者中风风险增加.
主要方法:
- 从2003年到2023年,在主要数据库 (PubMed,Google Scholar,Scopus,Web of Science,Science Direct) 进行了系统的文献搜索.
- 符合条件的研究包括原始的人类研究,定义了血糖学诊断标准 (ADA或WHO),并报告了生物标志物关联或中风风险.
- 在排除了具有主要并发症的研究后,包括了八项研究 (n=3003);偏差是使用纽卡斯尔-太华尺度评估的.
主要成果:
- 在高血糖患者中,持续报告了神经元特异性酶 (NSE) 的升高水平.
- 介乐-6 (IL-6) 显示出混合的结果,其中一项研究表明糖尿病的显著增加,另一项研究表明糖尿病前期的非显著上升趋势.
- 在中风或认知障碍的高血糖患者中,单个研究报告了D-二聚和GFAP的显著升高,而S100B的发现是分歧的.
结论:
- 在T2DM中观察到的生物标志物改变可能起源于糖尿病前期.
- 糖尿病前期患者可能表现出改变的炎症 (IL-6),凝血 (D-二次体) 和神经血管 (S100B,GFAP,NSE) 标志物.
- 进一步的强有力的研究对于验证这些关联和开发基于生物标志物的工具对于早期中风风险检测和糖尿病前期预防至关重要.
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