食品生物活性物代谢物针对心血管疾病的翻译后修饰:机制和治疗潜力
Hanya Dong1, Hai Jiang1, Haolin Yang2
1Key Laboratory of Basic and Application Research of Beiyao, (Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin 150040, China.
Journal of agricultural and food chemistry
|October 28, 2025
概括
来自食物和植物的天然产品可以通过调节蛋白质修饰来改善心血管疾病 (CVD). 这项研究阐明了这些天然化合物如何向翻译后修饰 (PTM) 来治疗心脏病.
科学领域:
- 生物化学 生物化学
- 药理学 药理学是指药理学的学科.
- 心脏病学 心脏病学
背景情况:
- 诸如心力衰竭 (HF),心肌梗塞 (MI) 和心肌缺血再流损伤 (MIRI) 等心血管疾病 (CVD) 是全球主要的死亡原因.
- 翻译后修饰 (PTMs) 是蛋白质功能,局部和心血管系统内的相互作用的关键调节者,影响心血管疾病的发病.
研究的目的:
- 系统地审查自然产品 (NP) 和它们的类似物改善心血管疾病的机制.
- 阐明NP如何调节PTM以抵消心血管病理.
- 为开发针对PTM的基于NP的疗法提供理论基础,用于预防和治疗心血管疾病.
主要方法:
- 文献综述和对天然产品及其对心血管疾病的影响现有研究的系统摘要.
- 分析各种类型的NP (黄类,多类,类,胺类) 调节PTMs的分子机制.
- 研究代谢物介导PTM在心血管疾病病理过程中的作用.
主要成果:
- 自然产品,包括黄类,多类,类和胺类,显示出改善心血管疾病的潜力.
- 通过调节特定PTM的水平和活动,NP发挥了有益的影响.
- 该研究阐明了NP干预,PTM监管和心血管疾病改善之间的直接联系.
结论:
- 天然产品通过向翻译后修改,为心血管疾病提供了有前途的治疗策略.
- 了解NP和PTM之间的分子相互作用为心脏病学中新药开发提供了基础.
- 这项工作强调了代谢物介导PTM在心血管健康和疾病管理中的重要性.
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