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细胞内二硫化物应激诱导的阿克丁功能障碍用于增强放射治疗的敏感性和引起抗瘤免疫力

Yang Liu^1,2, Cai Zhang¹, Zheng Deng¹

¹State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, The Fourth Affiliated Hospital of Soochow University, Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou 215123, China.

|October 28, 2025

概括

这项研究引入了一种新型纳米板 (CLDHP),通过诱导细胞循环停止来增强癌症放射治疗. CLDHP利用二硫化物压力来提高治疗效率并减少瘤生长.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
癌症研究癌症研究

背景情况:

放射治疗 (RT) 是癌症治疗的基石.
瘤的辐射敏感性对RT疗效至关重要.
开发增强辐射敏感性的策略是一个关键的研究领域.

研究的目的:

开发和评估一种用于放射敏感化的新型纳米板制剂 (CLDHP).
通过二硫化物应激来研究CLDHP诱导的放射敏感化机制.
评估CLDHP与RT和免疫疗法相结合的治疗疗效.

主要方法:

合成氨酸插入的多层双氧化物纳米片装载有素 (CLDHP).
通过二硫化物应激和NADPH耗尽来研究CLDHP诱导的G2/M相停止.
在体外和体内研究评估了CLDHP在增加RT敏感性和抑制瘤生长方面的疗效.
对CLDHP,RT和免疫检查点抑制剂联合治疗的评估.

主要成果:

在酸性瘤微环境中,CLDHP有效释放西斯和佛洛.
罗素抑制葡萄糖载体1型,导致NADPH耗尽和恶化的囊积累.
由CLDHP诱导的二硫化物应激会导致G2/M相停止,增强辐射敏感性.
在体内,CLDHP显著抑制瘤生长,并增强RT诱导的抗瘤免疫力.

结论:

CLDHP是一种安全有效的放射敏感剂,可通过二硫化物应力诱导G2/M相停止.
开发的纳米板策略为改善癌症放射治疗结果提供了一个有希望的方法.
与CLDHP,RT和免疫疗法的联合治疗显示出治疗原发性和转移性瘤的巨大潜力.

关键词:

在G2/M阶段.行为因子的功能障碍.硫化二氧化物的应力压力有层的双氧化.辐射疗法辐射疗法

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