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产前甲酸盐暴露和儿童过敏:结合线性/非线性建模揭示了关键窗口和性别差异

Yi-Ming Zhao1, Xin Chen1, Chen Han1

  • 1Department of Pediatrics, The First Affiliated Hospital of Anhui Medical University, No. 218 Jixi Road, Hefei, Anhui 230022, China; Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the Peoples Republic of China, No. 81 Meishan Road, Hefei, Anhui 230032, China.

Ecotoxicology and environmental safety
|October 28, 2025
PubMed
概括

产前接触某些酸盐与儿童过敏有关,如喘息和鼻炎. 这些影响取决于暴露的三个月和孩子的性别,观察到非线性剂量反应关系.

关键词:
过敏性鼻炎是一种过敏性鼻炎.亚托邦性皮肤炎 (Atopic Dermatitis) 是一种不良的疾病.线性和非线性关系.甲酸的含量 甲酸的含量经常出现的喘息声.

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In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
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