农药暴露与甲状腺癌之间的关联:系统性审查和元分析
1School of Public Health, Zunyi Medical University, Zunyi, Guizhou 563000, PR China.
Ecotoxicology and environmental safety
|October 28, 2025
概括
包括杀虫剂,除草剂和杀菌剂在内的农药暴露与增加甲状腺癌风险有关. 这种风险在女性中明显高于男性.
科学领域:
- 内分泌学 在内分泌学.
- 环境健康 环境健康
- 在瘤学瘤学.
背景情况:
- 甲状腺癌 (TC) 是全球普遍存在的内分泌恶性瘤.
- 农药暴露与TC之间的联系需要进行系统的调查.
- 了解这种关联对于公共卫生和风险评估至关重要.
研究的目的:
- 系统地评估暴露于各种农药 (杀虫剂,除草剂,杀菌剂) 和甲状腺癌之间的关系.
- 分析潜在的基于性别的差异在农药暴露和TC之间的关联.
- 使用元分析提供风险的定量总结.
主要方法:
- 进行了一项元分析,以综合有关农药暴露和TC的数据.
- 固定或随机效应模型用于计算几率比率 (OR) 和95%置信区间 (CI).
- 分析考虑了不同类型的农药,并按性别分层.
主要成果:
- 在暴露于杀虫剂 (OR=1.07),除草剂 (OR=1.10) 和杀菌剂 (OR=1.21) 和TC之间发现了积极的关联.
- 对于TC,女性的整体农药暴露风险 (OR=1.52) 比男性 (OR=0.95) 高.
- 具体的关联包括女性的杀虫剂和男性的杀菌剂的积极联系,以及男性除草剂的负面联系.
结论:
- 农药暴露被确定为甲状腺癌的重要危险因素.
- 与男性相比,女性在暴露于农药后患TC的风险似乎更高.
- 对性别特异性机制和有针对性的预防策略进行进一步研究是有必要的.
更多相关视频
04:14Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model
Published on: October 6, 2023
1.2K
16:02Demonstration of the Sequence Alignment to Predict Across Species Susceptibility Tool for Rapid Assessment of Protein Conservation
Published on: February 10, 2023
3.2K
相关概念视频
01:36Types of Toxins
3.1K
Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
3.1K
01:20Synthesis and Regulation of Thyroid Hormones
7.1K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
7.1K
01:18Functions of Thyroid Hormones
5.0K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
5.0K
01:26Toxic Reactions: Overview
1.8K
When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
1.8K
01:19Psychoneuroimmunology: Diabetes and Cancer
432
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
432
01:23Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
397
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
397