相关实验视频

Updated: Aug 9, 2026

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors

Published on: September 20, 2016

大脑转移的模式和肺腺癌的存活率与KRAS或EFGR突变

Martin Faehling¹, Sabine Fallscheer¹, Julia Schmiederer¹

¹Clinic of Cardiology and Pneumology, Esslingen Hospital, 73730 Esslingen, Germany.

Lung cancer (Amsterdam, Netherlands)

|October 28, 2025

概括

大脑转移 (BRA) 在具有KRAS或EGFR突变的非小细胞肺癌 (NSCLC) 中很常见. 虽然BRA没有影响KRAS或无驱动性NSCLC的存活率,但它恶化了EGFR突变NSCLC的结果.

科学领域:

在瘤学瘤学.
医学遗传学医学遗传学
放射学放射学是一门学科.

背景情况:

具有KRAS或EGFR突变的非小细胞肺癌 (NSCLC) 具有大脑转移 (BRA) 的高风险.
关于BRA患病率,模式和对未经选择的KRAS或EGFRNSCLC患者的生存影响的数据有限.

研究的目的:

分析BRA在KRAS,EGFR或没有已知的驱动突变的NSCLC患者的现实世界队列中的患病率,模式和整体生存 (OS) 影响.

主要方法:

对326名IV期NSCLC腺癌患者的现实世界分析.
分类为KRAS突变 (n=90),EGFR突变 (n=87) 或没有已知的驱动突变 (n=149) 组.
分析BRA患病率,数量,大小以及对OS的影响.

主要成果:

在KRAS (40%) 和EGFR (39%) 患者中,BRA的患病率高于没有驾驶者 (27%).
克拉斯和无驾驶患者经常有单个BRA;EGFR患者有多个BRA (中位数分别为1,2,4).
在KRAS或无驱动性NSCLC中,BRA的存在没有影响OS,但在EGFR突变NSCLC中显著恶化OS.

结论:

在KRAS/无驱动性NSCLC中,BRA缺乏OS影响可能与单个可治疗的转移有关.
在EGFR突变的NSCLC中BRA的负面OS影响表明了不同的生物学和多个非消灭性转移.

关键词:

中枢神经系统的转移.欧洲农业基金会 (EGFR) 是一个基金.在Exon 21中,Exon 21是第21个.在G12C中,G12C是指G12C.克拉斯 (Kras) 是一个国家.肺癌是一种肺癌.大脑转移的数量大脑转移的数量总体生存率总体生存率现实世界的数据数据.大小尺寸尺寸尺寸尺寸

更多相关视频

Establishing Dual Resistance to EGFR-TKI and MET-TKI in Lung Adenocarcinoma Cells In Vitro with a 2-step Dose-escalation Procedure

Establishing Dual Resistance to EGFR-TKI and MET-TKI in Lung Adenocarcinoma Cells In Vitro with a 2-step Dose-escalation Procedure

Published on: August 11, 2017

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer

Published on: July 21, 2018

相关概念视频

Adaptive Mechanisms in Cancer Cells

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...