低剂量的通过放大病毒受体和抑制杯状细胞分化来增强冠状病毒感染力
Yanan Cao1, Liangxing Xia1, Yanjie Huang1
1College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China.
Journal of hazardous materials
|October 28, 2025
概括
环境中的暴露会通过破坏肠道细胞和增加病毒进入,使猪三角型冠状病毒 (PDCoV) 感染恶化. 这种有毒金属破坏了肠道屏障,突出了环境因素和冠状病毒严重程度之间的关键联系.
科学领域:
- 环境科学 环境科学
- 病毒学 病毒学
- 毒理学 毒理学 毒理学
背景情况:
- 新出现的冠状病毒给全球健康带来了重大挑战.
- (Cd) 是一种有毒的环境金属,生物累积,其对病毒病原性的影响尚不清楚.
- 猪三角型冠状病毒 (PDCoV) 作为研究冠状病毒与环境相互作用的模型.
研究的目的:
- 调查 (Cd) 在恶化猪三角型冠状病毒 (PDCoV) 感染中的作用.
- 阐明Cd影响病毒病原性和宿主反应的机制.
- 了解环境毒素和病毒性疾病严重程度之间的相互作用.
主要方法:
- 使用猪模型和细胞培养物的体内,体外和体外实验.
- 对肠上皮细胞损伤的分析,包括微细菌的完整性和紧密结节的破坏.
- 评估病毒受体 (aminopeptidase N - APN) 表达和Notch信号通路的激活.
主要成果:
- 在所有测试模型中,暴露显著加剧了PDCoV感染.
- 通过破坏肠道上皮细胞和调高APN表达,Cd的积累增强了病毒的粘附和入侵.
- 通过Notch信号,CD抑制了杯状细胞的分化,恶化了粘膜屏障功能障碍,促进了感染.
结论:
- 通过双重机制增强了冠状病毒感染力:升调病毒受体表达,破坏肠道粘膜完整性.
- 这项研究为Cd诱导的病毒感染恶化提供了关键的机制性见解.
- 调查结果为减轻冠状病毒发病率和死亡率的公共卫生战略提供了信息,通过解决环境中毒物暴露问题.
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