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使用酵母显示和深度测序对GPCR配体C5a的高吞吐量突变表征

Yu Xu1, Kaushik Thakkar2, Li Guan2

  • 1Department of Radiation Oncology, Stanford University, Stanford, CA, USA; Department of Bioengineering, Stanford University, Stanford, CA, USA.

Structure (London, England : 1993)
|October 28, 2025
PubMed
概括

研究人员开发了一种使用脂质囊泡的新方法来研究G蛋白合受体 (GPCR) 和它们的连接体. 这种方法使得发现新的补充5a (C5a) 受体2 (C5aR2) 选择性连接体成为可能.

关键词:
G 蛋白结合受体的受体.高吞吐量选的高吞吐量选位点和 突变发生 突变发生酵母表面显示器显示酵母表面.

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