探索静脉注射甲索卡巴和急性损伤之间的联系
Matthew Li1,2, Avery Wilson3, Phillip Dudley4
1Department of Pharmacy, Westchester Medical Center, Valhalla, NY, USA.
Journal of pharmacy practice
|October 28, 2025
概括
静脉注射的肌肉松剂美托卡巴摩尔在危急病患者中没有显示出显著的损伤标志物. 这项研究没有发现血清肌素水平的变化,即使没有无药间隔,这表明ICU环境中的潜在安全性.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 关键护理医学 关键护理医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 甲索卡巴摩尔是一种IV骨肌肉放松剂,用于重症监护.
- 静脉甲醇含有聚乙烯糖醇 (PEG) 300和乙烯糖醇 (PG),与急性损伤 (AKI) 有关.
- 目前的指导方针建议限制72小时,然后进行48小时的无药间隔 (DFI),以尽量减少AKI风险.
研究的目的:
- 为了确定在接受IV methocarbamol的重症监护病房 (ICU) 患者中AKI的发病率.
- 评估IV美托卡巴摩尔对重症患者血清肌素 (SCr) 水平的影响.
主要方法:
- 对成年创伤或手术ICU患者的回顾性,单中心研究.
- 纳入标准:至少连续3次注射IV美托卡巴摩尔.
- 主要结局:从开始后的第1天到第7天的SCr差异,分析具有和没有DFI的队列.
主要成果:
- 68名患者符合纳入标准;4名患者属于非DFI组.
- 从第1天到第7天在整个队列中没有观察到中位数SCr水平的统计学上显著差异 (P = 0.55).
- 在没有DFI的患者中没有发现显著的SCr差异 (P = 0.84).
结论:
- 接受IV methocarbamol的危急病患者没有随着时间的推移显示出SCr在统计学上显著的变化.
- 在这种患者群体中,使用无药区间似乎没有影响SCr水平.
- 研究结果表明,IV美托卡巴摩尔可以在没有强制性DFI的情况下安全地给特定的ICU患者注射,这需要进一步调查.
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