在怀孕期间患有活跃牛皮关节炎的妇女中,先兆子更为常见:基于人口的研究
Carina Gotestam Skorpen1,2, Stian Lydersen3, Kjell Åsmund Salvesen4,5
1Rheumatology, Helse More og Romsdal HF, Alesund, Norway carina.skorpen@ntnu.no.
RMD open
|October 28, 2025
概括
活跃的牛皮关节炎 (PsA) 增加了怀孕期间高血压疾病的风险,包括先兆子. 然而,PsA似乎不会增加早产或胎儿生长异常的风险.
科学领域:
- 类风湿病学 类风湿病学
- 产科 产科 产科 产科 产科
- 公共卫生 公共卫生
背景情况:
- 牛皮关节炎 (PsA) 是一种慢性炎症性疾病.
- 患有PsA的女性怀孕可能与不良结果有关.
- 在怀孕期间PSA的外周疾病活动需要进一步调查.
研究的目的:
- 为了检查外围PsA疾病活动和怀孕并发症之间的关联.
- 为了调查PsA活动和子宫前,妊娠高血压,早产和胎儿生长之间的联系.
- 为了比较PSA患者的结果与人口对照的活跃与非活跃疾病.
主要方法:
- 使用挪威全国性注册表 (RevNatus和MBRN) 进行数据链接.
- 包括从2010年到2019年的患有PsA的女性单独分娩 (n=109) 和人口控制 (n=575,798)
- 在第二和第三季度使用DAS28-CRP评估PsA疾病活性;活跃的PsA定义为DAS28-CRP≥2.6.6.
主要成果:
- 与对照组 (2,6%) 相比,患有活跃PSA的女性 (8.8%) 的孕前发生的频率更高.
- 孕期高血压在活跃的PsA (5.9%) 和对照组 (1.7%) 中也更常见.
- 在PsA患者和对照人群之间没有观察到早产或胎儿生长异常的显著差异.
结论:
- 活跃的PsA与更高的妊娠高血压疾病发病率有关.
- 不活跃的PsA与高血压疾病没有显著的关联.
- 患有PsA的女性怀孕与早产或胎儿生长异常的风险增加无关.
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