在区域麻醉研究中优先考虑结果措施
Kariem El-Boghdadly1,2, Samer Narouze3, Amany Ezzat Ayad4
1Department of Anaesthesia and Perioperative Medicine, Guy's and St Thomas' NHS Foundation Trust, London, UK elboghdadly@gmail.com.
这项研究为区域麻醉研究制定了以患者为中心的优先事项,确定了疼痛得分和恢复质量等关键结果. 这些发现旨在提高急性疼痛临床试验的一致性和相关性.
科学领域:
- 麻醉学 麻醉学
- 疼痛管理 疼痛管理
- 临床研究方法论 临床研究方法论
背景情况:
- 区域麻醉和急性疼痛研究缺乏一致的结果选择.
- 当前的做法往往忽视了以患者为中心的优先事项和验证的工具.
- 这种不一致性阻碍了研究质量,一致性和相关性.
研究的目的:
- 优先考虑区域麻醉研究中的关键成果.
- 确定并提出适合这些结果的测量工具.
- 提高区域麻醉研究的质量,一致性和患者相关性.
主要方法:
- 一个多轮的Delphi过程,涉及专家和患者.
- 进行了两轮电子投票和一次面对面的会议.
- 结果和测量工具被评估为重要性,有效性和相关性.
主要成果:
- 在三轮德尔菲会议中,优先考虑了十个核心结果.
- 优先考虑的结果包括疗效测量 (疼痛评分,阿片类药物消费),多维测量 (康复质量) 和安全结果 (慢性术后疼痛).
- 患者特别优先考虑认知恢复,功能,慢性疼痛和疼痛得分.
结论:
- 建立了一个基于共识的,以患者为中心的区域麻醉研究优先事项框架.
- 未来的研究应该专注于开发一个特定于区域麻醉的恢复质量仪器.
- 标准化慢性疼痛和阿片类药物相关结果的报告对于方法一致性和患者相关性至关重要.
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