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Jean Krutmann¹, Anthony Brown², Thierry Passeron^3,4

¹IUF-Leibniz Research Institute for Environmental Medicine, Duesseldorf, Germany.

Photodermatology, photoimmunology & photomedicine

|October 29, 2025

概括

光保护成分 (PING) 通过抗氧化剂和DNA修复机制增强皮肤对阳光损伤的防御能力. 虽然一些PING显示出希望,但对于下一代防晒需要更多的研究.

科学领域:

皮肤病学皮肤病学
化品科学化品科学
光生物学的光学.

背景情况:

光保护成分 (PING) 是一种非过剂,可以增强皮肤对太阳辐射的自然防御能力.
PINGs通过抗氧化剂,DNA修复,免疫调节,抗炎和色素调节途径起作用,以防止或修复光损伤.
将PING纳入防晒提供了超越UV过器的保护,解决了传统防晒的局限性.

研究的目的:

审查和分类局部PING在光保护中的有效性.
确定具有强有力的临床和机械学证据来预防或修复光损伤的PING.
评估生物活性,配方兼容性和与关键光损伤终点相关性的PING.

主要方法:

对1700多个主题PING进行了专注的文献审查.
选择具有强大的临床和机械支持的成分.
评估生物活性,配方兼容性,以及对红斑,色素,光衰老和免疫抑制的影响.

主要成果:

排名第一的PINGs如L-亚斯科布酸,托科菲罗尔,光解酶和尼古丁胺在多个光损伤终点上显示出有效性.
抗氧化剂 (L-亚斯科布酸,托科菲醇) 保护免受UV和IR-A氧化应激.
DNA 修复酶 (光聚酶) 和尼古丁胺提升了DNA 修复和免疫功能.
颜色调节器有利于更深色的皮肤色调.

结论:

只有不到2%的候选PING被临床验证,只有18个被批准用于防晒.
使用PINGs对可见和红外辐射的保护尚未得到充分探索.
标准化测试和临床试验对于推进下一代防晒中的PINGs至关重要.

关键词:

修复DNA的修复DNA的修复抗氧化剂抗氧化剂是一种抗氧化剂.红外和可见光保护保护.尼古丁胺胺是什么尼古丁胺胺是什么不过的成分不过.氧化应激是一种氧化应激.照相酶是光聚酶的一种.照相保护照相保护皮肤的照片老化.防晒防晒防晒

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