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Updated: Jan 13, 2026

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
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预先确定的ATF4占用和染色体组织指示在综合应激反应期间选择性转录激活

Peipei Jiang1,2, Qian Bian3,4

  • 1Shanghai Institute of Precision Medicine, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Nature communications
|October 29, 2025
PubMed
概括

细胞通过综合应激反应 (ISR) 在压力期间快速调整基因表达. 这项研究表明,先前存在的转录因子结合和染色质结构在很大程度上预先确定了细胞应激反应.

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