在新辅助性全身性乳腺癌治疗试验中,地方区域治疗报告的一个核心结果
Shelley Potter1,2, Kerry Avery3,4,5, Rosina Ahmed6
1Bristol Surgical and Perioperative Care Complex Intervention Collaboration; Bristol Medical School, Bristol, UK. shelley.potter@bristol.ac.uk.
NPJ breast cancer
|October 29, 2025
概括
在新辅助全身疗法 (NST) 后准确报告乳腺癌治疗非常重要. 开发了一个新的核心结果集 (COS),以标准化和提高NST临床试验中地方区域结果报告的质量.
科学领域:
- 在瘤学瘤学.
- 临床试验 临床试验
- 手术瘤学手术瘤学
背景情况:
- 准确的局部区域性乳腺癌治疗报告后的新辅助全身疗法 (NST) 对于结果的解释至关重要.
- 目前的报告实践不一致,阻碍了对瘤结果的有意义分析.
- 需要采用标准化的方法来提高数据收集的质量和一致性.
研究的目的:
- 为了开发一个核心结果集 (COS) 的locoregional乳腺癌治疗后NST.
- 提高乳腺癌NST试验报告的质量,一致性和价值.
- 为研究和临床实践建立一套以共识为导向的基本成果.
主要方法:
- 开发遵循COS-STAD指导,涉及三个阶段.
- 第一个阶段:在101个领域中生成159个独特的局部区域结果.
- 第二阶段和第三阶段:国际Delphi调查 (470名专业人士) 和共识会议,以最终确定15项COS.
主要成果:
- 通过多方利益相关者的共识,最终确定了15项核心成果集 (COS).
- 该COS包括NST前的手术计划,治疗后的手术细节和放射治疗信息.
- 德尔菲调查取得了470名参与者的国际专业参与.
结论:
- 开发的15项COS将在乳腺癌NST试验中标准化地方区域结果报告.
- 预计这种COS的广泛实施将大大提高未来研究的质量和价值.
- 这种标准化将有助于更准确地解释乳腺癌治疗中的瘤学结果.
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