循环血管生物标志物与大动脉硬度和内皮功能在高血压中的生理指数相关
Andreas Jekell1, Mikael Ekholm2,3, Thomas Kahan2
1Division of Cardiovascular Medicine, Department of Clinical Sciences, Karolinska Institutet, Danderyd Hospital, Stockholm, Sweden. andreas.jekell@ki.se.
Scientific reports
|October 29, 2025
概括
这项研究发现,在高血压患者中,循环内皮细胞生物标志物,如氨酸 (HA) 和syndecan-1 (SDC-1),与血管功能的生理测量表现出微弱的关联. 结合这些标志物可能会提供对内皮质健康的额外见解.
科学领域:
- 心血管研究研究心血管研究
- 血管生物学 血管生物学
- 生物标志物发现发现
背景情况:
- 内皮功能障碍是高血压和心血管疾病的关键因素.
- 循环生物标志物和生理评估用于评估血管健康,但它们之间的关系尚未完全理解.
- 有限的研究同时研究了循环内皮细胞生物标志物和非侵入性生理血管功能方法.
研究的目的:
- 在高血压患者中同时评估循环内皮细胞生物标志物和生理非侵入性血管方法之间的关系.
- 评估内皮糖成分 (hyaluronan,syndecan-1) 和粘附分子与各种血管功能的相关性.
- 为了确定这些生物标志物是否与血管功能有关,独立于估计的膜过率 (eGFR).
主要方法:
- 与酶相关的免疫吸收试验 (ELISA) 用于测量循环中的生物标记物:氨酸 (HA),syndecan-1 (SDC-1),ICAM-1,VCAM-1和E-selectin.
- 通过脉冲波分析评估大动脉硬度 (cfPWV),大动脉内皮功能 (流介导扩张),较小阻力动脉功能 (β2-上腺受体激动剂刺激) 和皮肤微血管功能 (激光多普勒流量计,离子泳).
- 在107名高血压患者中,通过心声扫描评估了透缩功能和左心房大小,这些患者具有广泛的eGFR.
主要成果:
- 氨 (HA) 独立地与大动脉硬度 (cfPWV) 相关.
- 辛德肯-1 (SDC-1) 独立地与皮肤微血管功能有反向关系,并与阻力动脉内皮功能有积极关系.
- 所有测量的循环生物标志物与大动脉内皮功能和心声回声学参数无关. 葡萄糖标记物与EGFR独立的生理指标有关联,但关系很弱.
结论:
- 循环内皮细胞生物标志物,特别是葡萄糖成分,与高血压患者血管功能的特定生理测量具有独立的关联.
- 由于关系较弱,这些生物标志物不应该被用作生理测量的直接代理.
- 将循环生物标志物与生理评估结合起来,可以提供关于整体血管功能和内皮健康的补充信息.
相关概念视频
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
531
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
531
Hypertension III: Clinical Manifestations and Diagnostic Studies
462
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
462
Hypertension and Regulation of Blood Pressure
3.7K
Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
3.7K
Vascular Resistance
10.0K
Vascular resistance is a critical concept in understanding blood flow dynamics in the circulatory system. It refers to the resistance that blood encounters as it flows through the blood vessels. This resistance is a key factor in determining blood pressure and cardiac workload.
The primary determinants of vascular resistance are vessel diameter, blood viscosity, and vessel length. Among these, vessel diameter plays the most significant role due to the fourth power relationship described by...
The primary determinants of vascular resistance are vessel diameter, blood viscosity, and vessel length. Among these, vessel diameter plays the most significant role due to the fourth power relationship described by...
10.0K
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests
455
Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
455
Hypertension II: Pathophysiology
771
Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
771


