在男性患有良性前列腺增生和膀出口阻塞的前列腺炎症和排卵细胞过活之间的关联:一个前性泌尿动力学和组织学研究
Evangelos Varelas1, Georgios Antoniadis2, Aikaterini Tsionga3
12nd Urology Department, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Prostate cancer and prostatic diseases
|October 29, 2025
概括
前列腺炎症 (PI) 在男性中较为常见,这些男性患有脱子过度活跃 (DO),并且与良性前列腺增生 (BPH) 手术后的持续症状有关. 准PI可能会改善与BPH相关的下尿路症状 (LUTS) 的结果.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 病理学 病理学 病理学
背景情况:
- 在老年男性中,良性前列腺增生 (BPH) 通常会导致膀出口阻塞 (BOO) 和下泌尿道症状 (LUTS).
- 在BOO手术后,detrusor过度活动 (DO) 往往会持续下去.
- 前列腺炎症 (PI) 在DO病变发生中的作用尚不清楚.
研究的目的:
- 在经过尿道切除前列腺切除 (TURP) 的BPH男性中,调查组织前列腺炎症 (PI) 和脱体过活性 (DO) 之间的关联.
主要方法:
- 对125名男性 (≥50岁) 进行前性观察研究,这些男性患有BPH,BOO和中度至重度的LUTS,正在接受TURP.
- 在TURP前后进行尿动力学测试,以评估DO.
- 用伊朗分数对切除的前列腺组织进行组织学检查,以评分PI.
主要成果:
- 在78.4%的患者中存在PI,在DO患者中明显更频繁 (84.9%与69.2%对比).
- 中度至重度PI与TURP后持续的DO相关 (OR=4.00).
- 在75.3%的患者中,DO消失了,但持久性与显著的PI有关.
结论:
- 前列腺炎症在患有DO的男性中更为普遍和严重.
- PI与 TURP 后的 DO 持久性有关.
- PI可能是管理与BPH相关的LUTS和DO的治疗目标.
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