构造性和破坏性细胞生物化学的激活能量决定了古生物的最大生长温度
Antonin Affholder1,2, Régis Ferrière3,4,5, François Guyot6
1Institut de Biologie de l'École Normale Supérieure, École Normale Supérieure, Université PSL, Paris, France. antoaffh@gmail.com.
Communications biology
|October 29, 2025
概括
物种的最大生长温度是由细胞建设性和破坏性过程之间的平衡所驱动的. 这一发现表明微生物生命可能适应温度超出目前已知的极限.
科学领域:
- 微生物学 微生物学
- 生物物理学的生物物理.
- 进化生物学 进化生物学
背景情况:
- 特定物种的最大生长温度 (MGT) 通常由细胞功能不可逆转的丧失来解释.
- 假设MGT是破坏性细胞过程超过建设性的热点.
研究的目的:
- 评估MGT是由细胞建设性和破坏性过程之间的平衡决定的假设.
- 开发基于特征的细胞生长模型来研究MGT驱动因素.
主要方法:
- 开发了一种基于特征的细胞生长模型,使用建设性和破坏性过程的激活能量.
- 在古生物的生长曲线上应用贝叶斯反转来推断特征值.
- 将推断的特征值映射到最大生长温度.
主要成果:
- 建设性和破坏性过程的激活能量之间的差异被确定为MGT变化的主要驱动因素.
- 在激活能量之间发现了线性缩放关系,解释了最大和最佳生长温度之间的相关性.
- 这种缩放表明微生物可能适应超过110-120°C的温度.
结论:
- 细胞的建设性和破坏性过程能量平衡是微生物热极限的基础.
- 鉴定的缩放关系为微生物的热适应提供了机制基础.
- 这项研究为发现比目前已知的更高温度的生命开辟了可能性.
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