精子DNA完整性和不育男性的性功能障碍: DFI和性功能障碍
Gilad Karavani1, Justin Chan2, Yulia Wilk Goldsher3,4
1Division of Urology, Department of Surgery, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada. Giladk84@gmail.com.
Journal of assisted reproduction and genetics
|October 29, 2025
概括
高精子DNA碎片化 (DFI) 与男性勃起功能障碍 (ED) 有关. 这项研究建议将性健康查整合到男性不孕症评估中,以解决这一问题.
科学领域:
- 生殖医学 生殖医学
- 安德罗学与人类学
- 男人的健康 男人的健康
背景情况:
- 精子DNA碎片化 (DFI) 影响男性生育能力.
- 性功能障碍 (SD) 在男性中很常见,影响生活质量.
- DFI和SD之间的关系需要进一步调查.
研究的目的:
- 评估精子DNA碎片化指数 (DFI) 和性功能障碍 (SD) 之间的关联.
- 通过男性性健康清单 (SHIM) 评估勃起功能障碍的严重程度,并通过老年男性雄激素缺乏症 (ADAM) 问卷评估丸素缺乏症的症状.
- 为了确定不育男性性功能的预测因素.
主要方法:
- 703名不育男性 (2000-2020年) 的回顾性队列研究.
- 收集的数据包括SHIM和ADAM问卷,精液分析和DFI测试.
- DFI被分为正常 (<30%) 或异常 (≥30%). 多变量回归分析了性功能的预测因素.
主要成果:
- 在39%的男性中发现了异常的DFI.
- 患有异常DFI的男性的SHIM得分明显较低,表明更严重的勃起功能障碍 (p=0.02).
- 较高的BMI (>30 kg/m2) 与减少性交频率有关;吸烟和积极的ADAM分数与较差的SHIM分数相关.
结论:
- 异常的精子DNA碎片化显著与勃起功能障碍有关.
- 这些发现强调了在男性不孕症评估中评估性健康的重要性.
- 整合SD评估可以改善患者护理和andrology诊所的结果.
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