在不育群体中,自发和ART分娩的分娩时间
Marie-Caroline Compans1,2, Eva Beaujouan3, Vegard Skirbekk4,5
1University of Vienna (Wittgenstein Centre for Demography and Global Human Capital - IIASA, OeAW, University of Vienna), Vienna, Austria. marie-caroline.compans@ined.fr.
BMC women's health
|October 29, 2025
概括
通过辅助生殖技术 (ART) 实现活产需要比自发受孕更长的时间,平均为五年而不是三年. 然而,自2000年以来,ART的成功率有所提高,特别是在30多岁后期试图怀孕的女性中.
科学领域:
- 生殖医学 生殖医学
- 人口统计学 人口统计学
- 公共卫生 公共卫生
背景情况:
- 在高收入国家,延迟生育与与年龄相关的不孕症增加有关.
- 辅助生殖技术 (ART) 提供解决方案,但往往需要大量的时间.
- 关于不孕症患者,有或没有ART的活产时间及其时间趋势的数据有限.
研究的目的:
- 调查在经历不孕症的个体中实现活产所需的时间.
- 为了比较活出分娩的时间,有和没有ART.
- 分析这些时间线在不同时期如何演变.
主要方法:
- 关于怀孕尝试时间的HUNT研究数据的回顾性分析.
- 将HUNT数据与挪威医疗出生登记处 (NMBR) 联系起来,用于活产和ART跟踪.
- 使用来自863名母亲和590名父亲的数据的考克斯模型,比较1987-1999年和2000-2019年的数据.
主要成果:
- 自发分娩的平均时间:3年;ART分娩的平均时间:5年.
- 在2000-2019年,与1987-1999年相比,两种性别的ART分娩的时间显著减少.
- 在35-39岁年龄组怀孕加速了ART分娩,但不是自发分娩.
结论:
- 在不育的个体中,ART可以促进活产,但通常需要更多的时间.
- 自2000年以来,实现ART分娩的时间缩短了,特别是对于那些在三十多岁末开始尝试的人来说.
- 尽管存在与年龄相关的挑战,ART效率,患者个人资料和寻求护理行为的改善可能有助于缩短ART时间表.
相关概念视频
01:24In Vitro Fertilization
874
In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
874
01:28Infertility in Females
3.6K
Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of...
Endometriosis, a condition characterized by abnormal growth of...
3.6K
01:23Infertility in Males
522
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
522
01:41Spermatogenesis
121.6K
Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
121.6K
01:38Fertilization
89.6K
During fertilization, an egg and sperm cell fuse to create a new diploid structure. In humans, the process occurs once the egg has been released from the ovary, and travels into the fallopian tubes. The process requires several key steps: 1) sperm present in the genital tract must locate the egg; 2) once there, sperm need to release enzymes to help them burrow through the protective zona pellucida of the egg; and 3) the membranes of a single sperm cell and egg must fuse, with the sperm...
89.6K
01:57Meiosis II
206.7K
Meiosis II is the second and final stage of meiosis. It relies on the haploid cells produced during meiosis I, each of which contain only 23 chromosomes—one from each homologous initial pair. Importantly, each chromosome in these cells is composed of two joined copies, and when these cells enter meiosis II, the goal is to separate such sister chromatids using the same microtubule-based network employed in other division processes. The result of meiosis II is two haploid cells, each...
206.7K