断奶时的微生物继承是由宿主甘氨酸的微生物代谢指导的
Jean-Bernard Lubin1, Paul J Planet2,3,4, Michael A Silverman5,6,7,8
1Division of Infectious Disease, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA. jb.lubin@path.utah.edu.
Microbiome
|October 29, 2025
概括
主体甘氨酸对于在关键的断奶过渡期间塑造肠道微生物群至关重要. 了解微生物对甘氨酸的利用,可以帮助开发有利于益生菌引入和增强免疫发育的策略.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
背景情况:
- 断奶期间从牛奶过渡到固体食物显著影响正在发展的肠道微生物群和免疫系统.
- 影响奶时肠道微生物继承的关键微生物和宿主因素尚不清楚.
研究的目的:
- 为了研究断奶期间微生物继承的动态.
- 了解宿主糖甘利用在微生物殖民和免疫成熟中的作用.
主要方法:
- 与哺乳期前 (PedsCom) 和成年 (Oligo-MM12) 微生物群落共存的 gnotobiotic 小鼠.
- 微生物碳水化合物活性酶的基因组分析.
- 在体内验证使用降解粘液的微生物Akkermansia muciniphila.
主要成果:
- 同居成功地回顾了与断奶相关的微生物继承和诱导的免疫成熟.
- 具有高宿主甘氨酸利用能力的微生物是最有效的殖民者.
- 与成人联盟不同,PedsCom社区缺乏降解宿主甘氨酸的酶.
- 阿克尔曼西亚 (Akkermansia) muciniphila的殖民依赖于代谢粘素甘氨酸.
结论:
- 宿主衍生的甘氨酸在断奶期间在塑造肠道微生物群落中发挥着至关重要的作用.
- 主体甘氨酸代表调节肠道微生物群和增强免疫发育的潜在目标.
- 针对糖甘利用的策略可以促进在断奶期间引入有益的益生菌.
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