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Alexander Vladimirovich Ivanov¹, Mikhail Aleksandrovich Popov^1,2, Polina Alexandrovna Pudova¹

¹Institute of General Pathology and Pathophysiology, Baltiyskaya St., 8, 125315 Moscow, Russia.

Diagnostics (Basel, Switzerland)

|October 29, 2025

概括

血中低氨酸 (CysS) 水平可能表明严重的急性中风. 这一发现可能有助于早期识别中风的严重程度,特别是在缺血性或出血性中风患者中.

科学领域:

生物化学生物化学
神经学神经学
临床医学临床医学

背景情况:

氨酸 (Cys) 是一种氨基酸,在中风期间的神经元损伤中至关重要.
血中存在各种形式的Cys,包括减少的Cys及其二硫化物囊 (CysS).
Cys形式与急性中风严重程度之间的联系需要进一步调查.

研究的目的:

调查急性中风患者的总Cys,减少Cys和CysS的血水平.
确定这些Cys形式在入院时对中风严重性的影响.

主要方法:

对210名患有缺血性中风和出血性中风的患者 (39-59岁) 的分析.
血Cys形式的测量在入院后10-72小时内.
使用NIHSS和修改的兰金度表 (mRs) 评估中风严重程度.

主要成果:

血CysS水平低于54μM与严重的神经缺陷相关 (NIHSS>13).
这种关联对于缺血性中风 (RR = 5.58,p = 0.0021) 和出血性中风 (RR = 3.56,p = 0.0003) 都具有意义.
吸烟,高总Cys,以及其他类硫醇水平 (谷氨酸,同氨酸) 影响了这种关系.

结论:

低血CysS水平可能作为急性中风严重程度的潜在生物标志物.
这一发现可能有助于早期识别和治疗中风患者.

关键词:

氨基乙醇 (aminothiols) 是一种氨基乙醇.半氨酸 (cysteine) 是一种氨酸.神经学缺陷的神经学缺陷脑中风标记器脑中风标记器

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