儿科急性尾炎的唾液生物标志物:目前的证据和未来的方向
Zenon Pogorelić1,2, Miro Jukić1,2, Tomislav Žuvela3
1Department of Pediatric Surgery, University Hospital of Split, 21000 Split, Croatia.
Children (Basel, Switzerland)
|October 29, 2025
概括
唾液生物标志物显示出对儿童尾炎的诊断有前途,提供一种非侵入性的替代方案. 唾液中的C-反应蛋白 (CRP) 显示出高准确性,这表明改善儿科尾炎诊断的潜力.
科学领域:
- 儿科手术 儿科手术
- 生物标志物 生物标志物
- 诊断医学 诊断医学
背景情况:
- 急性尾炎是一种常见的儿科手术紧急情况,具有诊断挑战.
- 目前的诊断方法 (临床,成像,血液测试) 有局限性.
- 唾液为生物标志物检测提供了一个非侵入性,无痛和儿童友好的替代方案.
研究的目的:
- 系统地审查关于用于诊断儿科尾炎的唾液生物标志物的文献.
- 评估已识别的唾液标记物的诊断准确性.
主要方法:
- 在主要数据库 (Ovid/MEDLINE,Scopus,Web of Science,Cochrane Library) 进行系统的文献搜索.
- 纳入标准:对怀疑/确认尾炎的儿童进行的研究,评估唾液标志物.
- 与临床,实验室或成像诊断标准进行比较.
主要成果:
- 研究了三个唾液生物标志物:富含白的α-2-糖蛋白1 (LRG1),C反应蛋白 (CRP) 和虹膜蛋白.
- 唾液CRP显示出高的诊断性能 (AUC 0.97,灵敏度91.3%,特异性95.4%) 并与血清CRP有很强的相关性.
- LRG1具有高特异性 (100%),但敏感性低 (35-36%);虹膜素显示出作为辅助标记物的潜力 (AUC ~ 0.75).
结论:
- 唾液生物标志物对儿科尾炎有希望,但需要进一步研究.
- 目前的证据仅限于小型,单中心研究.
- 未来的研究应该专注于多中心验证,多标记面板和生物传感器技术,用于点的护理测试.
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