异常的胎儿/新生儿肺部发育表现为某些功能性心脏异常在胎儿生命的第三个三个月
Julia Murlewska1, Oskar Sylwestrzak1,2, Maciej Słodki1,3
1Department of Prenatal Cardiology, Polish Mother's Memorial Hospital Research Institute, 93-338 Lodz, Poland.
Biomedicines
|October 29, 2025
概括
在妊娠晚期的产前心声扫描可以识别特定的发现,如心室不成比例和肺动脉扩张,预测新生儿肺高血压 (PH) 的发展. 早期识别有助于计划分娩和对这种严重疾病的新生儿护理.
科学领域:
- 新生儿心脏病学 新生儿心脏病学
- 胎儿心声学 胎儿心声学
- 肺高血压是什么意思 肺高血压
背景情况:
- 新生儿肺高血压 (PH) 是一种罕见的,危及生命的疾病,由于类似的心声学发现,经常被误诊为先天性心脏病.
- 关于产前预测产后PH的预测因素的证据有限,需要进一步调查.
- 这项研究侧重于怀疑有大动脉缩 (CoA) 的婴儿,并分析了与产后PH相关的第三季度心声学发现.
研究的目的:
- 描述详细的第三个月的心声回声检测结果,预测产后PH在怀疑大动脉缩 (CoA) 的婴儿.
- 在子宫内识别肺血管适应能力受损的潜在标志物.
- 为指导患病婴儿的分娩计划和新生儿监测.
主要方法:
- 追溯案例系列分析了18年的胎儿心声学数据 (2004-2022).
- 确定的胎儿怀疑怀孕晚期的CoA,在预期产生的,长时间的新生儿住院 (>10天) 并且没有心脏手术/导管.
- 根据心声和临床标准计算心脏尺寸和确认产后PH的Z-score.
主要成果:
- 在138名怀疑COA的婴儿中,有8名婴儿 (0.04%) 发展出产后PH (70个假阳性).
- 产前发现包括心室/心房不成比例,心壮病,主要肺动脉扩张 (Z评分+2.7),三回,肺回和心室间隔膜增大.
- 所有受影响的新生儿都需要重症监护;三名死亡,而五名在医疗管理下幸存下来.
结论:
- 特定的第三季度心声学异常可以预测产后PH,特别是在最初怀疑CoA的病例中.
- 这些发现表明肺血管适应能力受损,可以为分娩和新生儿护理策略提供信息.
- 需要进行前性的多中心研究来验证这些预测因素,并完善产前查方案.
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