患移植后恶性瘤的风险因素 在移植接受者中
Kalliopi Vallianou1, Ioannis Bellos1,2, Vassilis Filiopoulos1
1Clinic of Nephrology and Renal Transplantation, Medical School, National and Kapodistrian University of Athens, Laiko Hospital, 11527 Athens, Greece.
Biomedicines
|October 29, 2025
概括
癌症对接受移植的人来说是一个重大威胁. 拒绝病史和丸炎作为主要脏疾病增加恶性瘤的风险,而不是特定的免疫抑制剂.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
背景情况:
- 恶性瘤是移植患者死亡的主要原因,全球发病率不断增加.
- 了解新的恶性瘤的发生频率和相关因素对于患者的治疗结果至关重要.
研究的目的:
- 为了估计移植患者中新发性恶性瘤的发生率.
- 为了确定与移植后恶性瘤发展相关的风险因素.
主要方法:
- 从1979年到2023年,对2986名移植患者进行了回顾性分析.
- 对患有和没有新发性恶性瘤的患者进行比较,根据年龄,性别和移植年份进行匹配.
- 多变量逻辑回归用于确定癌症发展的风险因素.
主要成果:
- 8.98%的接受者 (268/2986) 患有恶性瘤,移植后的中位数发病时间为8年.
- 肺癌和移植后淋巴增殖性疾病是最常见的恶性瘤.
- 拒绝病史 (OR=1.75) 和作为原发性病的血球炎 (OR=2.23) 是显著的危险因素.
结论:
- 移植患者的癌症发生与免疫抑制的整体负担有关.
- 特定的免疫抑制药物没有被确定为新发恶性瘤的独立风险因素.
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