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微生物群调节作为一种预防与犬类无皮炎相关的抗菌药物的使用的方法
Tânia Lagoa1,2,3, Luís Martins1,4, Maria Cristina Queiroga1,4
1MED-Mediterranean Institute for Agriculture, Environment and Development & CHANGE-Global Change and Sustainability Institute, Universidade de Évora, Polo da Mitra, Ap. 94, 7006-554 Évora, Portugal.
Biomedicines
|October 29, 2025
概括
调节肠道微生物群为治疗狗皮炎提供了抗生素的有希望的替代方案. 诸如益生菌和便微生物群移植等干预措施可以恢复微生物平衡,改善皮肤健康,同时打击抗菌素耐药性.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 兽医皮肤病学 兽医皮肤病学
背景情况:
- 现代生活方式因素会破坏肠道微生物群,通过肠-皮肤轴影响免疫反应和皮肤健康.
- 肠道功能失调与皮肤疾病有关,并驱动抗菌药物的使用,导致像MRSP这样的多药耐药生物体.
- 抗菌素耐药性 (AMR) 对人类和动物健康构成重大威胁,需要采取替代策略.
研究的目的:
- 审查微生物群调制作为一种替代性/补充性方法,用于抗微生物治疗犬皮炎 (cAD).
- 评估诸如益生菌,益生菌,后生菌和便微生物群移植等干预措施在管理cAD方面的潜力.
- 评估这些策略在恢复微生物平衡,增强上皮质完整性和缓解AMR方面的作用.
主要方法:
- 文献综述侧重于研究肠道微生物群调节对狗皮肤状况的研究.
- 对包括益生菌,益生菌,后生菌和便微生物群移植在内的干预措施的分析.
- 评估它们对微生物平衡,肠-皮肤轴和抗菌素耐药性的影响.
主要成果:
- 肠道微生物群的失调与免疫功能受损以及皮肤疾病的患病率增加有关.
- 慢性皮肤疾病往往导致抗微生物药物的使用增加,促进多药耐药生物.
- 微生物群调节策略显示出恢复肠道平衡和改善狗皮肤健康的潜力.
结论:
- 微生物群调节代表了一种可行的替代和补充策略,用于抗微生物治疗犬皮炎.
- 诸如益生菌,益生菌,后生菌和便微生物群移植等干预措施可以恢复微生物平衡并加强肠道屏障.
- 这些方法对管理皮肤疾病和对抗伴侣动物抗菌素耐药性充满希望.
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