草甘对甲状腺有什么影响? 一个更新的审查
Lomesh Choudhary1, Mathilda Monaghan2, Rebecca Schweppe3
1Michael G. DeGroote School of Medicine, McMaster University, Hamilton, ON L8P 1A2, Canada.
Biomedicines
|October 29, 2025
概括
草甘是一种常见的除草剂,可能会破坏甲状腺功能. 虽然一些人体研究显示出混合的结果,但动物和体外研究表明潜在的甲状腺激素干扰,需要进一步调查草甘.
科学领域:
- 环境健康 环境健康
- 内分泌学 在内分泌学.
- 毒理学 毒理学 毒理学
背景情况:
- 甲状腺功能障碍和癌症的增加率可能与内分泌干扰化学物质 (EDC) 有关.
- 草甘是一种广泛使用的除草剂,具有内分泌干扰性质.
- 甲状腺对EDCs和全球草甘暴露的敏感性需要调查.
研究的目的:
- 综合审查关于草甘/草甘基除草剂 (GBH) 与甲状腺功能障碍之间的关联的研究.
- 总结人类,动物和体外研究的发现.
主要方法:
- 在PubMed,Scopus和Embase的系统文献搜索到2024年12月.
- 包括28项原始研究:9项人类研究,3项体外研究和16项动物研究.
- 提取研究设计,人群/模型,暴露和甲状腺结果的数据.
主要成果:
- 人类研究提出了关于草甘暴露和甲状腺激素水平的混合发现.
- 动物研究 (动物,两动物) 表明甲状腺激素的干扰和基因表达的改变,特别是在发育性暴露时.
- 试验室研究显示对甲状腺相关基因转录和细胞活性的影响,但是在高度下.
结论:
- 有证据表明草甘可能会破坏甲状腺功能,但研究变异使得这一发现复杂化.
- 人群,暴露评估,物种和剂量的差异阻碍了直接比较.
- 需要进一步的机制和纵向研究来阐明草甘的甲状腺特异性风险.
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