在生物材料支架中利用植物生物活性化合物进行先进的伤口愈合:综合性审查
Nur Syazana Sabarudin1,2, Norshazliza Ab Ghani1, Nazeha Ahmat1
1Department of Tissue Engineering and Regenerative Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Cheras, Kuala Lumpur 56000, Malaysia.
Biomedicines
|October 29, 2025
概括
在生物材料支架中集成的植物生物活性化合物为先进的伤口愈合提供了有希望的战略. 这些富含植物化学物质的支架可以对抗感染,减少炎症,并促进组织再生,以改善治疗结果.
科学领域:
- 生物材料科学 生物材料科学
- 药理学 药理学是指药理学的学科.
- 再生医学是一种再生医学.
背景情况:
- 伤口愈合面临抗生素耐药性病原体,炎症和氧化应激的挑战.
- 传统疗法往往不足以复杂的伤口愈合.
- 植物生物活性化合物 (植物化学物质) 具有抗微生物,抗炎和抗氧化特性,有利于伤口修复.
研究的目的:
- 审查纳入生物材料支架的植物生物活性化合物的潜力,以增强伤口愈合.
- 探索这些复合系统如何应对诸如植物化学品的溶解性差和不稳定性等挑战.
- 评估脚手架在提供植物化学物质以改善伤口再生方面的有效性.
主要方法:
- 在PubMed,Scopus和Web of Science (1998-2025) 的结构化文献搜索.
- 关键词:伤口愈合,植物化学物质,植物生物活性化合物,脚手架,水凝,电,3D生物打印.
- 对将植物化合物纳入各种生物材料支架的研究进行分析.
主要成果:
- 植物化学架构复合材料显示出对抗耐药性病原体的抗菌活性.
- 这些系统有效地减轻了伤口部位的氧化应激和炎症.
- 脚手架增强了植物生物活性化合物的稳定性,生物可用性和持续释放,促进了血管生成和组织再生.
结论:
- 将植物生物活性化合物集成到生物材料支架中,代表了下一代伤口愈合疗法的有前途战略.
- 脚手架改善了植物化学物质的传递,解决了溶解性和稳定性的限制.
- 进一步研究脚手架设计,配方标准化和临床翻译对于治疗应用至关重要.
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