关于健康个体以及肥胖和慢性疾病人群中VEGF水平的运动干预的最佳类型和剂量:一个网络元分析
Liqun Jiang1, Huimin Ding1, Dongjun Lee1
1Graduate School of Physical Education, Myongji University, Yongin 17058, Republic of Korea.
Biomedicines
|October 29, 2025
概括
运动类型和强度显著影响血管内皮生长因子 (VEGF) 水平. 下肢阻力训练对健康成年人有好处,而低氧条件下的联合训练有助于肥胖者,中度上肢阻力训练有助于慢性疾病.
科学领域:
- 运动生理学 运动生理学
- 血管生物学 血管生物学
- 慢性疾病管理 慢性疾病管理
背景情况:
- 血管新生障碍和血管功能障碍是慢性疾病的标志.
- 血管内皮生长因子 (VEGF) 对于血管修复和代谢调节至关重要.
- 运动对VEGF的影响报告不一致,需要进行系统审查.
研究的目的:
- 系统地比较运动方式和剂量对不同人群中VEGF水平的影响.
- 确定最佳的运动策略,以调节健康成年人,肥胖者和慢性病患者的VEGF.
主要方法:
- 按照PRISMA指南进行系统审查和网络元分析.
- 在PubMed,科学网,Embase和Cochrane图书馆搜索到2025年1月.
- 使用代谢等价物 (MET) 和分析剂量反应关系的标准化运动剂量.
主要成果:
- 在健康的成年人中,下肢阻力训练产生了最高的VEGF增加 (~1950 METs-min/week).
- 在低氧条件下进行有氧和阻力训练的组合对肥胖个体来说是有希望的.
- 适度的上肢阻力训练 (756-950METs-min/week) 对慢性疾病最有效,显示出U形的剂量反应.
结论:
- 运动诱导的VEGF反应是群体和剂量依赖的.
- 高强度下肢阻力训练可以优化健康成年人的血管适应.
- 考虑到人群和剂量,量身定制的运动处方对于VEGF介导的血管健康至关重要.
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