区域大脑体积在成年期的变化:使用MRI数据的多队列研究
Jae Hyuk Shim1, Hyeon-Man Baek1,2, Jung Hoon3
1MTech Lab Co., Ltd., Room B1027, 119, Songdo Munhwa-ro, Yeonsu-gu, Incheon 21985, Republic of Korea.
Brain sciences
|October 29, 2025
概括
随着年龄的增长,大脑结构发生变化,心室显著膨胀,前额叶和头顶叶收缩. 这为正常衰老与疾病提供了一个参考.
科学领域:
- 神经成像是一种神经成像.
- 大脑衰老 老化大脑
- 认知神经科学 认知神经科学
背景情况:
- 与年龄相关的大脑结构变化对于理解认知衰老和神经退行性疾病至关重要.
- 在成年期表征规范性大脑体积变化对于识别健康衰老的偏差至关重要.
研究的目的:
- 在成年期 (年龄21-90岁) 的95个大脑区域中全面绘制与年龄相关的体积变化.
- 整合多种MRI数据集 (韩国,IXI,ADNI) 以进行规范性大脑衰老的强有力的表征.
主要方法:
- 利用一个优化的神经成像管道与先进的预处理和神经网络细分在T1加权的MRI从1833个认知健康的个人.
- 分析了七个年龄段的体积数据,与FreeSurfer相比验证了管道可靠性 (平均ICC:0.9965).
- 对性别和队列效应进行了校正,然后计算了整个生命周期内双边大脑体积的百分比变化.
主要成果:
- 观察到白质过敏度 (122.6%) 和侧腔室 (115.9%) 的显著体积膨胀.
- 在额头 (三角形: 21.5%),头部 (下面的头部: 20.4%),部 (横向的部: 21.6%) 和带状皮层 (16.1%) 中记录了中度到显著的收缩.
- 在insula (3.7%) 和pallidum (2.6%) 中发现了最小的体积变化.
结论:
- 这项研究为整个成年期的规范性区域大脑体积变化提供了全面的参考.
- 突出了与年龄相关的大脑体积变化的实质性区域间变异性.
- 提供了区分正常衰老和大脑早期病理变化的基础.
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