游泳如何调节疼痛,神经退行性和代谢障碍中的炎症途径
Mahdiyeh Kooshki1,2, Rozhin Rezeai-Farimani2,3,4, Amirmohammad Moradpour1,3,4
1Patient Safety Research Center, Clinical Research Institute, Mashhad University of Medical Sciences, Mashhad 9177948564, Iran.
Brain sciences
|October 29, 2025
概括
定期游泳运动可以减少全身的炎症. 这种低影响性活动增强了抗炎药物,可能降低心血管,神经和类风湿病的风险.
科学领域:
- 运动免疫学 运动免疫学
- 分子生物学分子生物学
- 系统性审查 系统性审查
背景情况:
- 游泳是一种非负重的全身运动,具有潜在的抗炎功效.
- 它可以通过调节免疫反应来降低心血管,神经和类风湿疾病的风险.
- 本综述检查了游泳在通过炎症途径免疫调节中的作用的证据.
研究的目的:
- 系统地审查关于游泳运动对免疫反应和炎症的影响的证据.
- 确定参与游泳诱导的抗炎作用的特定分子和细胞机制.
主要方法:
- 在PubMed和Scopus数据库上进行了系统的文献搜索,直到2024年12月.
- 使用与游泳和炎症相关的关键词,产生了509篇文章.
- 在对相关性,语言和全文可用性进行选后,有102篇文章符合纳入标准.
主要成果:
- 游泳通过增强BDNF,CREB和PI3K/Akt信号传递而减少神经炎症,同时抑制NF-κB,TNF-α和IL-6.
- 它通过激活SIRT1和PGC-1α来改善线粒体生物发生和代谢组织中的抗氧化剂防御.
- 游泳通过调节PPAR-α,eNOS和eNOS,以及通过IL-10,IL-1β和CRP产生全身抗炎作用,减少血管炎症,氧化应激和和心脏组织纤维化.
结论:
- 游泳是一种低冲击,全身运动,在与炎症相关的疾病中具有潜在的治疗应用.
- 它在治疗心血管疾病,糖尿病和肥胖方面表现有前途.
- 未来的研究应该优先考虑人类临床试验,机械学研究和长期评估.
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