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暴露和膀癌:从TCGARNA-Seq和毒基因组整合中获得的分子见解

Gözde Öztan¹, Halim İşsever², Tuğçe İşsever³

¹Department of Medical Biology, Istanbul Faculty of Medicine, Istanbul University, Topkapı, 34093 Istanbul, Turkey.

|October 29, 2025

概括

暴露会通过激活特定的基因表达程序来影响膀癌 (BC). 这些程序涉及细胞粘附和信号通路,可能提供预后见解,AQP12B显示作为生物标志物的潜力.

科学领域:

在瘤学瘤学.
环境健康环境健康
毒素基因组学毒素基因组学

背景情况:

膀癌 (BC) 是一个重大的全球健康挑战.
将 (Pb) 暴露与BC联系起来的分子机制在很大程度上仍未被探索.
调查BC中的Pb响应基因表达对于理解疾病病原和识别生物标志物至关重要.

研究的目的:

为了确定是否在膀癌中存在敏感的转录程序.
评估这些方案的临床相关性和预后价值.
评估一个复合的-响应得分,用于BC的风险分层.

主要方法:

对TCGA膀泌尿腺癌 (BLCA) RNA-seq数据的差异基因表达分析.
来自CTD的精选的相关基因在BLCA差异表达基因 (DEGs) 中进行了丰富测试.
计算了瘤水平的-反应得分,并使用Cox模型评估其与整体存活时间 (OS) 的关联.

主要成果:

在BLCA DEG中发现了与相关的基因的显著丰富 (p < 10^-9).
发现的关键途径包括突触/神经元类粘附,MAPK信号传递和细胞循环控制.
AQP12B被确定为OS的独立预后标志物 (p = 0.0038);-反应得分显示了预后值的趋势 (p = 0.045).

结论:

在膀癌中存在敏感的转录程序,影响粘附,MAPK信号传递和细胞循环通路.
AQP12B作为膀癌的预后生物标志物显示出希望.
一个复合的-反应得分需要进一步验证,以便在风险分层中临床应用.

关键词:

膀癌:膀癌是一种癌症.基因基因基因基因暴露于的情况.预后标志物是一个预后标志物.毒性基因组学毒性基因组学

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