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肝细胞癌增长动力学和跨动脉栓塞后的结果:单中心分析

Ken Zhao¹, Harrison Blume¹, Elena N Petre¹

¹Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

|October 29, 2025

概括

快速增长的肝细胞癌 (HCC),以短时间的瘤体积翻倍时间 (TVDT) 表示,与经过动脉栓塞 (TAE) 后的生存率较差有关. 遗传突变与更快的HCC生长没有相关性.

科学领域:

肝胆瘤学肝胆瘤学
干预性放射学是干预性的放射学.
癌症基因组学癌症基因组学

背景情况:

肝细胞癌 (HCC) 是一种具有重大全球影响的原发性肝癌.
跨动脉栓塞 (TAE) 是对不可切除的HCC的常见治疗方法.
了解影响治疗反应和生存的因素对于HCC管理至关重要.

研究的目的:

调查瘤体积翻倍时间 (TVDT) 与TAE治疗的HCC患者的临床结果之间的关联.
评估瘤基因型对HCC的TVDT的影响.
为了确定 HCC 的 TAE 后生存的预后因素.

主要方法:

对接受TAE的先前未接受治疗的HCC患者进行了回顾性队列研究.
从基线横截面成像中使用施瓦茨方程计算的TVDT.
为基因突变分析进行的下一代测序.
用于生存评估的卡普兰-梅尔和考克斯回归分析.

主要成果:

较短的TVDT (≤2.5个月) 与TAE后的整体存活率 (OS) 更差有关 (p=0.011).
更糟糕的生存状况的预测因素包括TVDT ≤2.5个月,ECOG性能得分为1-2,AFP>200 ng/mL.
多重HCC瘤 (≥5) 预测局部瘤无进展存活率 (LTPFS) 较差 (p=0.002).
没有发现任何特定的基因突变与较短的TVDT有关.

结论:

较短的TVDT表明瘤快速生长,可能预测TAE治疗的HCC患者的生存状况较差.
瘤基因型似乎不是HCC生长速度 (TVDT) 的重要因素.
TVDT是接受TAE的HCC患者的潜在预后标志物.

关键词:

增长动力学的增长动力学肝细胞癌是肝细胞癌.通过动脉栓塞的跨动脉栓塞

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