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Updated: Jan 13, 2026

Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA
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Published on: December 19, 2019

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增加EGFR/HER2通路激活有助于Tpl2小鼠皮肤瘤发生

Laura R Purkey1, Stefania Mehedincu1, Charles Irvine1

  • 1Department of Biology, American University, Washington, DC 20016, USA.

Cancers
|October 29, 2025
PubMed
概括

在小鼠中,瘤进展部位2 (Tpl2) 的丧失加速了皮肤癌. 用Gefitinib或Lapatinib准ErbB信号减少了瘤的发展,这表明皮肤状细胞癌 (cSCC) 的潜在治疗方法.

关键词:
欧洲农业基金会 (EGFR) 是一个基金.这就是ErbB2的意思.在HER2中,HER2是HER2.在MAP3K8K中,您可以使用MAP3K8K.在Tpl2上,我们可以使用Tpl2.cSCCCC 的意思是什么?在 miR-205 之前,它是 miR-205.据报道,米R-21的发射器为米R-21

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